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Abilify (6)

Abilify is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Abilify appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the… View Drug & Imprints

Acetaminophen (85)

Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor… View Drug & Imprints

Acyclovir (47)

A guanosine analog antiviral drug that acts as an antimetabolite. Acyclovir is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles). Acyclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. Currently approved drugs for the treatment of herpes labialis (cold sores)… View Drug & Imprints

Adderall (14)

Adderall is a chiral compound. The racemic mixture can be divided into its optical antipodes: levo- and dextro-adderall. Adderall is the parent compound of its own structural class, comprising a broad range of psychoactive derivatives, e.g., MDMA (Ecstasy) and the N-methylated form, methadderall. Adderall is a homologue of phenethylamine. Adderall and dextroadderall, non-catechloamine sypathomimetic agents,… View Drug & Imprints

Albuterol (22)

Albuterol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD . It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Albuterol is formulated as a racemic mixture of the R- and… View Drug & Imprints

Aleve (2)

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. Aleve is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Aleve has analgesic and antipyretic properties. As with… View Drug & Imprints

Allopurinol (25)

A xanthine oxidase inhibitor that decreases uric acid production. It also acts as an antimetabolite on some simpler organisms. Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid… View Drug & Imprints

Alprazolam (113)

A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA  Drug Evaluations Annual, 1994, p238) Alprazolam, a benzodiazepine, is used to treat panic disorder and anxiety disorder. Unlike chlordiazepoxide, clorazepate, and prazepam, alprazolam has a shorter half-life… View Drug & Imprints

Ambien (1)

Ambien also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP ) is an experimental sleep aid drug developed by Lundbeck and Merck. In March, 2007, Merck and H. Lundbeck cancelled work on the drug, citing safety concerns and the failure of an efficacy trial. It acts on the GABA system, but possibly in a different way from benzodiazepines, nonbenzodiazepines… View Drug & Imprints

Amiodarone (16)

An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance. Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide… View Drug & Imprints

Amitriptyline (70)

Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA ). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs… View Drug & Imprints

Amlodipine (210)

Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition… View Drug & Imprints

Amoxicillin (38)

A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation. Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range… View Drug & Imprints

Aricept (3)

Aricept (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer’s disease where it is used to increase cortical acetylcholine. Aricept is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its… View Drug & Imprints

Aspirin (54)

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra… View Drug & Imprints

Atenolol (46)

A cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect. Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing… View Drug & Imprints

Ativan (6)

A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. Ativan, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. The most important clinical adverse… View Drug & Imprints

Atorvastatin (66)

Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG -CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG -CoA reductase catalyzes the conversion of HMG -CoA to mevalonate. Atorvastatin acts primarily in the… View Drug & Imprints

Augmentin (7)

Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase. Clavulanic acid, produced by the fermentation of Streptomyces Clavuligerus, is a… View Drug & Imprints

Azithromycin (24)

Azithromycin is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending… View Drug & Imprints

Baclofen (22)

Baclofen is a gamma-amino-butyric acid (GABA ) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA -B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic… View Drug & Imprints

Bactrim (2)

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the bactrim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Bactrim resistance has been reported. Bactrim is… View Drug & Imprints

Belsomra (4)

Belsomra is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. Dose-related somnolence and CNS depression are the most common adverse effects associated with the use of belsomra. It has also been shown to impair driving skills… View Drug & Imprints

Belviq (1)

Belviq (previously APD -356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Belviq is marketed as a salt… View Drug & Imprints

Benadryl (2)

Benadryl is a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. Benadryl is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce… View Drug & Imprints

Benicar (3)

Benicar is an antihypertensive agent, which belongs to the class of medications called angiotensin II receptor blockers. It is indicated for the treatment of high blood pressure and is marketed under the name Olmetec®. The FDA label includes a black-box warning of injury and death to the fetus, so women of child-bearing age need to… View Drug & Imprints

Biaxin (2)

Biaxin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Biaxin may be bacteriostatic or bactericidal depending on the organism and drug concentration. Biaxin is a macrolide… View Drug & Imprints

Bisoprolol (14)

Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Bisoprolol is structurally similar to metoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to… View Drug & Imprints

Boniva (4)

Boniva is a nitrogen-containing bisphosphonate in the same class as alendronate and risedronate. Boniva inhibits osteoclast-mediated bone resorption. All of the bisphosphonates prevent the breakdown of bone by bone cells called osteoclasts. In persons who are at high risk for osteoporosis, bisphosphonates not only result in increased amounts of bone and bone strength, they also… View Drug & Imprints

Brilinta (2)

Brilinta (trade name Brilinta in the US, Brilique and Possia in the EU) is a platelet aggregation inhibitor produced by AstraZeneca. Unlike clopidogrel, brilinta is not a prodrug and does not require metabolic activation. The drug was approved for use in the European Union by the European Commission on December 3, 2010. The drug was… View Drug & Imprints

Brintellix (4)

Brintellix is an atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD ). It is classified as a serotonin modulator and simulator (SMS ) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of… View Drug & Imprints

Bupropion (69)

A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. Bupropion, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin… View Drug & Imprints

Buspar (2)

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam. Buspar is used in the treatment of generalized anxiety where it has advantages over other antianxiety drugs because it does not cause sedation… View Drug & Imprints

Buspirone (53)

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam. Buspirone is used in the treatment of generalized anxiety where it has advantages over other antianxiety drugs because it does not cause sedation… View Drug & Imprints

Bystolic (4)

Bystolic is a highly cardioselective vasodilatory beta1 receptor blocker used in treatment of hypertension. In most countries, this medication is available only by prescription. Bystolic is a competitive and highly selective beta-1 receptor antagonist with mild vasodilating properties, possibly due to an interaction with the L-arginine/nitric oxide pathway. In preclinical studies, bystolic has been shown… View Drug & Imprints

Carbamazepine (47)

An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of phenytoin; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar. Carbamazepine, an anticonvulsant structurally similar to tricyclic antidepressants, is used to… View Drug & Imprints

Carvedilol (49)

Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF ). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors. Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity and is indicated for the treatment of hypertension and mild or moderate… View Drug & Imprints

Celebrex (4)

Celebrex is a non-steroidal anti-inflammatory drug (NSAID ) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra…. View Drug & Imprints

Celexa (3)

Celexa hydrobromide belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Celexa and its N-demethylated metabolites exist as a racemic mixture but its effects are largely due to the S-enantiomer, S-celexa and S-demthylcelexa. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant… View Drug & Imprints

Cephalexin (49)

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that… View Drug & Imprints

Cetirizine (53)

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic… View Drug & Imprints

Cialis (4)

Cialis is an orally adminstered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Cialis’s distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of… View Drug & Imprints

Cipro (5)

A broad-spectrum antimicrobial carboxyfluoroquinoline. Cipro is a broad-spectrum antiinfective agent of the fluoroquinolone class. Cipro has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including cipro, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to… View Drug & Imprints

Ciprofloxacin (62)

A broad-spectrum antimicrobial carboxyfluoroquinoline. Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to… View Drug & Imprints

Citalopram (94)

Citalopram hydrobromide belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Citalopram and its N-demethylated metabolites exist as a racemic mixture but its effects are largely due to the S-enantiomer, S-citalopram and S-demthylcitalopram. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant… View Drug & Imprints

Claritin (3)

Claritin is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. Claritin is a long acting second generation antihistamine that is similar in structure to cyproheptadine and… View Drug & Imprints

Clindamycin (26)

Clindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration. Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin… View Drug & Imprints

Clonazepam (40)

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses. Clonazepam, a benzodiazepine, is used primarily as an anticonvulsant… View Drug & Imprints

Clonidine (43)

Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone…. View Drug & Imprints

Concerta (4)

A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. Concerta is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Concerta also blocks the reuptake… View Drug & Imprints

Coreg (8)

Coreg is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF ). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors. Coreg is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity and is indicated for the treatment of hypertension and mild or moderate… View Drug & Imprints

Coumadin (18)

Coumadin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Coumadin has since become the most frequently prescribed oral anticoagulant in North America. Coumadin has several properties that should be noted when used medicinally, including its ability to cross… View Drug & Imprints

Crestor (8)

Crestor is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG -CoA) reductase. HMG -CoA reducuase catalyzes the conversion of HMG -CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Crestor belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. Crestor is a… View Drug & Imprints

Cyclobenzaprine (41)

Cyclobenzaprine is a skeletal muscle relaxant and a central nervous system (CNS ) depressant. Cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing… View Drug & Imprints

Cymbalta (4)

Cymbalta (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD ), generalized anxiety disorder (GAD ), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI ). It is manufactured and marketed by Eli Lilly and Company. Cymbalta… View Drug & Imprints

Demerol (2)

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. Meperidine is a synthetic opiate agonist… View Drug & Imprints

Depakote (3)

Valproic acid, supplied as the sodium salt valproate semisodium or divalproex sodium, is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium… View Drug & Imprints

Dexamethasone (16)

An anti-inflammatory 9-fluoro-glucocorticoid. Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions. Oral, rat LD50: >3 gm/kg. Signs of overdose include… View Drug & Imprints

Dextromethorphan (17)

The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the… View Drug & Imprints

Diazepam (28)

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and… View Drug & Imprints

Diclofenac (46)

A non-steroidal anti-inflammatory agent (NSAID ) with antipyretic and analgesic actions. It is primarily available as the sodium salt. Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis Symptoms of overdose include loss… View Drug & Imprints

Diflucan (4)

Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS . Diflucan, a synthetic antifungal agent of the imidazole class, is used to treat vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the fungal cell membrane…. View Drug & Imprints

Digoxin (18)

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone digoxigenin. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm… View Drug & Imprints

Dilantin (2)

An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to… View Drug & Imprints

Dilaudid (10)

An opioid analgesic derived from morphine and used mainly as an analgesic. It has a shorter duration of action and is more potent than morphine. Dilaudid is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Dilaudid is approximately 8 times more potent… View Drug & Imprints

Diltiazem (109)

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal’s variant angina. Diltiazem is a non-dihydropyridine (DHP)member of… View Drug & Imprints

Diovan (7)

Diovan is an angiotensin-receptor blocker (ARB ) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Diovan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS ); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood… View Drug & Imprints

Diphenhydramine (119)

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. Diphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation… View Drug & Imprints

Ditropan (2)

Ditropan is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination, by decreasing muscle spasms of the bladder. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. Ditropan is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with… View Drug & Imprints

Doxazosin (54)

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It may be used to mild to moderate hypertension and in the management of symptomatic benign prostatic hyperplasia (BPH ). α1-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate… View Drug & Imprints

Doxycycline (126)

A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and… View Drug & Imprints

Effexor (5)

Effexor (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI ) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that effexor may significantly increase the risk of suicide it is not recommended as a first… View Drug & Imprints

Effient (4)

Effient, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, effient is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing activation of the GPIIb/IIIa receptor… View Drug & Imprints

Elavil (9)

Elavil hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA ). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, elavil does not affect mood or arousal, but may cause sedation. In depressed individuals, elavil exerts a positive effect on mood. TCAs… View Drug & Imprints

Eliquis (2)

Eliquis is an oral, direct, and highly selective factor Xa (FXa) inhibitor (of both free and prothrombinase-bound FXa independently of antithrombin III ) for the prevention and treatment of thromboembolic diseases. It is marketed under the name Eliquis. FDA approved on December 28, 2012. Eliquis acts by inhibiting coagulation, and thus prevents development of blood… View Drug & Imprints

Enalapril (51)

Enalapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE ) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalaprilat is a potent, competitive inhibitor of ACE , the enzyme responsible for the conversion of angiotensin I (ATI ) to angiotensin II (ATII ). ATII regulates… View Drug & Imprints

Endocet (6)

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. Endocet, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Endocet is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette… View Drug & Imprints

Entresto (3)

Entresto is a neprilysin inhibitor and is used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV). The combination drug, entresto/valsartan is used in place of an ACE inhibitor or ARB . It was approved under the FDA’s priority review process for use in… View Drug & Imprints

Ephedrine (32)

An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of… View Drug & Imprints

Erythromycin (31)

Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. Erythromycin is produced… View Drug & Imprints

Estrace (6)

Generally refers to the 17-beta-isomer of estrace, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estrace-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The… View Drug & Imprints

Estradiol (75)

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The… View Drug & Imprints

Etodolac (43)

Etodolac is a non-steroidal anti-inflammatory drug (NSAID ) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. Etodolac is an anti-inflammatory agent with analgesic and antipyretic properties. It is used to treat… View Drug & Imprints

Evista (1)

A second generation selective estrogen receptor modulator (SERM ) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue. Evista, a selective estrogen receptor modulator (SERM) of the benzothiophene class, is similar to tamoxifen in… View Drug & Imprints

Excedrin (16)

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Excedrin’s most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several… View Drug & Imprints

Exelon (4)

Exelon is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type. Exelon is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase. Exelon is a parasympathomimetic and a reversible cholinesterase inhibitor. An early pathophysiological feature of Alzheimer’s disease that is associated with memory loss and cognitive deficits… View Drug & Imprints

Exforge (9)

Exforge is an angiotensin-receptor blocker (ARB ) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Exforge lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS ); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood… View Drug & Imprints

Ezetimibe (1)

Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes. Ezetimibe is in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption… View Drug & Imprints

Famotidine (45)

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of… View Drug & Imprints

Farxiga (2)

Farxiga is indicated for the management of diabetes mellitus type 2, and functions to improve glycemic control in adults when combined with diet and exercise. Farxiga is a sodium-glucose cotransporter 2 inhibitor, which prevents glucose reabsorption in the kidney. Using farxiga leads to heavy glycosuria (glucose excretion in the urine), which can lead to weight… View Drug & Imprints

Femara (1)

Femara (INN , trade name Femara®) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Femara blocks production of estrogens in this way by competitive, reversible binding to the heme of… View Drug & Imprints

Fenofibrate (61)

An antilipemic agent which reduces both cholesterol and triglycerides in the blood. Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as… View Drug & Imprints

Fentanyl (18)

A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078) Fentanyl is an opioid analgesic. Fentanyl interacts predominately with the opioid… View Drug & Imprints

Fetzima (4)

Fetzima is a selective serotonin and norepinephrine reuptake inhibitor. Chemically, fetzima is the 1S,2R-enantiomer of milnacipran. FDA approved on July 25, 2013. Fetzima binds with high affinity to human serotonin (5-HT) and norepinephrine (NE) transporters (Ki = 11 and 91 nM, respectively). It potently inhibits 5-HT and NE reuptake (IC50 = 16 – 19 and… View Drug & Imprints

Fioricet (4)

Fioricet, 5-allyl-5-isobutylbarbituric acid, is a barbiturate with an intermediate duration of action. It has the same chemical formula as talbutal but a different structure. Fioricet is often combined with other medications, such as acetaminophen or aspirin, and is commonly prescribed for the treatment of pain and headache. Fioricet is a short to intermediate-acting barbiturate. Barbiturates… View Drug & Imprints

Flagyl (2)

A nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed). Flagyl, a synthetic… View Drug & Imprints

Flexeril (4)

Flexeril is a skeletal muscle relaxant and a central nervous system (CNS ) depressant. Flexeril acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing… View Drug & Imprints

Flomax (1)

Flomax is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of… View Drug & Imprints

Fluoxetine (72)

Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks… View Drug & Imprints

Focalin (11)

Focalin is the dextrorotary form of methylphenidate. It is a norepinephrine-dopamine reuptake inhibitor (NDRI ) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD ). Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Insomnia, dizziness, nausea,… View Drug & Imprints

Folic Acid (18)

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. Folic acid, a water-soluble B-complex vitamin, is found… View Drug & Imprints

Fosamax (8)

Fosamax is an oral gallium compound that enables oral absorption of the active ingredient contained in Ganite™ (gallium nitrate injection). It targets bone tissue and is actively incorporated into bone mineral at sites where bone is metabolically active. Fosamax is one of a class of gallium containing compounds that were originally developed by the U.S…. View Drug & Imprints

Furosemide (43)

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. Profound diuresis may cause fluid… View Drug & Imprints

Gabapentin (88)

Gabapentin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, gabapentin is widely used to relieve pain, especially neuropathic pain. Gabapentin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized. Gabapentin, an analog of GABA, is used as an anticonvulsant to… View Drug & Imprints

Gemfibrozil (16)

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not… View Drug & Imprints

Genvoya (1)

Genvoya, used as Genvoya fumarate (TAF ), is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), TAF has greater antiviral activity… View Drug & Imprints

Geodon (4)

Geodon (marketed as Geodon, Zeldox) was the fifth atypical antipsychotic to gain FDA approval (February 2001). Geodon is Food and Drug Administration (FDA ) approved for the treatment of schizophrenia, and the intramuscular injection form of geodon is approved for acute agitation in schizophrenic patients. Geodon has also received approval for acute treatment of mania… View Drug & Imprints

Gilenya (1)

Gilenya is a sphingosine 1-phosphate receptor modulator indicated and approved for the treatment of relapsing-remitting multiple sclerosis. Gilenya causes a transient reduction in heart rate and AV conduction at treatment initiation. Potential to prolong the QT interval. Effects on immune cell numbers in the blood- decreased lymphocyte counts. Mild decrease in the neutrophil count- about… View Drug & Imprints

Gilotrif (3)

Gilotrif is a tyrosine kinase inhibitor which is a 4-anilinoquinazoline. It is prepared has the dimaleate salt. FDA approved on July 12, 2013. Gilotrif did not effect the QTc interval. Most common adverse reactions (≥20%) are diarrhea, rash/dermatitis, acneiform, stomatitis, paronychia, dry skin, decreased appetite, pruritus.

Gleevec (2)

Gleevec, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML ). In June 2006, a Phase I clinical trial found gleevec has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (Gleevec®), another tyrosine kinase inhibitor… View Drug & Imprints

Glipizide (37)

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized. Glipizide, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II. The primary mode of action of glipizide in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet… View Drug & Imprints

Glucophage (3)

A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290) Used to treat diabetes, glucophage is a biguanide (contains… View Drug & Imprints

Glucotrol (10)

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized. Glucotrol, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II. The primary mode of action of glucotrol in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet… View Drug & Imprints

Glucovance (3)

Glucovance is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM ). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose,… View Drug & Imprints

Glyburide (57)

Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM ). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose,… View Drug & Imprints

Glyxambi (2)

Glyxambi is a DPP -4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Two pharmacological characteristics that sets glyxambi apart from other DPP -4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011. Glyxambi is… View Drug & Imprints

Gralise (2)

Gralise (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, gralise is widely used to relieve pain, especially neuropathic pain. Gralise is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized. Gralise, an analog of GABA, is used as an anticonvulsant to… View Drug & Imprints

Guaifenesin (90)

An expectorant that also has some muscle relaxing action. It is used in many cough preparations. Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that… View Drug & Imprints

Harvoni (1)

Harvoni is a prodrug nucleotide analog used as part of combination therapy to treat hepatitis C virus (HCV ) infection or to treat co-infection of HIV and HCV . After metabolism to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-triphosphate (also known as GS-461203), the triphosphate serves as a defective substrate for the NS5B protein, an RNA -dependent… View Drug & Imprints

Hetlioz (1)

Hetlioz is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and… View Drug & Imprints

Horizant (4)

Gabapentin enacarbil is marketed under the name Horizant®. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS ) and postherpetic neuralgia (PHN ). Since Horizant is a prodrug of gabapentin, it’s physiological effects are the same as gabapentin. Concerning PHN, gabapentin prevents allodynia and hyperalgesia. Most… View Drug & Imprints

Hydrochlorothiazide (284)

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. Thiazides such… View Drug & Imprints

Hydrocodone (102)

Narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant. Hydrocodone, a semisynthetic opiate agonist and hydrogenated ketone derivative, is similar to other phenanthrene derivatives, such as codeine. Used as an analgesic, hydrocodone is combined with acetaminophen, ibuprofen, or aspirin to treat pain. Used as… View Drug & Imprints

Hydroxychloroquine (11)

A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine possesses antimalarial properties and also exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known. Symptoms of overdose include headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed… View Drug & Imprints

Hydroxyzine (70)

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine,… View Drug & Imprints

Hysingla Er (21)

A benzazepine derived from norbelladine. It is found in galanthus and other amaryllidaceae. Hysingla Er is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine, and has been studied as a treatment for Alzheimer’s disease and other central nervous system disorders. Hysingla Er is a parasympathomimetic, specifically,… View Drug & Imprints

Hytrin (4)

Hytrin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH ). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel… View Drug & Imprints

Hyzaar (5)

Hyzaar is an angiotensin-receptor blocker (ARB ) that may be used alone or with other agents to treat hypertension. Hyzaar and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS ); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood… View Drug & Imprints

Ibrance (3)

Ibrance is an oral, reversible, selective, small-molecule inhibitor of CDK4 and CDK6 indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. CDK4 and CDK6 along with their regulatory partner cyclin D1… View Drug & Imprints

Ibuprofen (116)

Ibuprofen, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, which are thought to act through inhibition of prostaglandin synthesis…. View Drug & Imprints

Imbruvica (1)

Imbruvica is a small molecule anti-cancer drug that targets B-cell malignancies. In November 2013 imbruvica was approved by the FDA for the treatment of mantle cell lymphoma, and later in February 2014 for the treatment of chronic lymphocytic leukemia. Imbruvica is also indicated for the treatment of patients with Waldenström’s Macroglobulinemia (WM). Imbruvica is marketed… View Drug & Imprints

Imdur (5)

Isosorbide mononitrate is a drug used principally in the treatment of angina pectoris1 and acts by dilating the blood vessels so as to reduce the blood pressure. It is sold by AstraZeneca under the trade name Imdur. Isosorbide mononitrate is used to for the the prophylactic treatment of angina pectoris; that is, it is taken… View Drug & Imprints

Imitrex (6)

A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraine disorders. A transdermal patch version of imitrex is currently in phase I trials in the U.S. under the code name NP101 (NuPathe). Imitrex, an antimigraine drug, is a selective agonist of vascular serotonin ((5-hydroxytryptamine; 5-HT) type 1-like receptors,… View Drug & Imprints

Imodium (5)

One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. Imodium is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic… View Drug & Imprints

Inderal (5)

A widely used non-cardioselective beta-adrenergic antagonist. Inderal is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. Inderal, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is… View Drug & Imprints

Intelence (3)

Intelence is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor(NNRTI ). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV -1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of intelence 100mg tablets in the treatment of adult HIV -1 infection… View Drug & Imprints

Intuniv (4)

A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation. Intuniv is a phenylacetyl-guanidine derivative hypotensive and a centrally-acting, alpha(2)-adrenergic receptor agonist used… View Drug & Imprints

Invega (8)

Invega is the primary active metabolite of the older antipsychotic risperidone. While its specific mechanism of action is unknown, it is believed that invega and risperidone act via similar if not the same pathways. It has been proposed that the drug’s therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2… View Drug & Imprints

Invokamet (4)

Invokamet belongs to a new class of anti-diabetic drugs that works by inhibiting the sodium-glucose transport protein (SGLT2). This transport protein is found in the kidney and is responsible for reabsorbing glucose that has been filtered. FDA approved on March 29, 2013. Invokamet binds to SGLT2 more potently (250-times) than SGLT1 in vitro. The 50%… View Drug & Imprints

Invokana (2)

Invokana belongs to a new class of anti-diabetic drugs that works by inhibiting the sodium-glucose transport protein (SGLT2). This transport protein is found in the kidney and is responsible for reabsorbing glucose that has been filtered. FDA approved on March 29, 2013. Invokana binds to SGLT2 more potently (250-times) than SGLT1 in vitro. The 50%… View Drug & Imprints

Iressa (1)

Iressa (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), iressa selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. Iressa inhibits the intracellular phosphorylation of numerous tyrosine kinases associated… View Drug & Imprints

Isentress (3)

Isentress is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA ) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.

Isosorbide (86)

A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. Isosorbide is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and… View Drug & Imprints

Jakafi (5)

Jakafi is a janus-associated kinase inhibitor indicated to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis. FDA approved on November 16, 2011. The mean half-maximal inhibitory concentration (IC50) for JAK 1 and JAK 2 are 2.8 nmol/L and 3.3 nmol/L respectively. After administration of jakafi, a decrease in levels of phosphorylated STAT (marker for… View Drug & Imprints

Jalyn (1)

Jalyn is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of… View Drug & Imprints

Janumet (5)

Janumet is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP -4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. The drug works to competitively inhibit a protein/enzyme, dipeptidyl peptidase 4 (DPP… View Drug & Imprints

Januvia (3)

Januvia is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP -4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. The drug works to competitively inhibit a protein/enzyme, dipeptidyl peptidase 4 (DPP… View Drug & Imprints

Jardiance (2)

Jardiance is a sodium glucose co-transporter-2 (SGLT -2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes. SGLT2 co-transporters are responsible for reabsorption of glucose from the glomerular filtrate in the kidney. The glucuretic effect resulting from SGLT2 inhibition reduces renal absorption and lowers… View Drug & Imprints

Jentadueto (3)

Jentadueto is a DPP -4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Two pharmacological characteristics that sets jentadueto apart from other DPP -4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011. Jentadueto is… View Drug & Imprints

Juxtapid (3)

Juxtapid is a microsomal triglyceride transfer protein (MTP ) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid®. Juxtapid directly inhibits microsomal triglyceride transfer protein (MTP). Contra-indicated in pregnancy, and moderate to severe hepatic insufficiency (Child-Pugh category B or C). Severe GI adverse reactions may occur.

K-dur (2)

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The potassium ion is in the principle intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission… View Drug & Imprints

Kadian (12)

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Kadian has widespread effects in the central nervous system and on smooth muscle. Kadian is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Kadian interacts predominantly with the… View Drug & Imprints

Kaletra (3)

Kaletra (ABT -378) is an antiretroviral of the protease inhibitor class. It is marketed by Abbott as Kaletra, a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV /AIDS . Kaletra is an antiretroviral of the protease inhibitor class. Inhibiting HIV-1 protease (responsible for protein cleavage), results in… View Drug & Imprints

Kalydeco (1)

Kalydeco (also known as Kalydeco or VX-770) is a drug for the treatment of cystic fibrosis, developed by Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. FDA approved on January 31, 2012. Kalydeco is a cystic fibrosis transmembrane conductance regulator (CFTR). In patients with the G551D mutation, Kalydeco, a pill taken two times a day with… View Drug & Imprints

Kapvay (4)

Kapvay, an imidazoline-derivative hypotensive agent is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone…. View Drug & Imprints

Kazano (2)

Kazano is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP -4). Chemically, kazano is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013. Peak inhibition of DPP-4 occurs within 2-3 hours after… View Drug & Imprints

Keflex (12)

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. Keflex (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that… View Drug & Imprints

Keppra (6)

Keppra is an anticonvulsant medication used to treat epilepsy. Keppra may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Keppra binds to the synaptic vesicle protein SV2A, which is thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of keppra binding to synaptic vesicle protein SV2A… View Drug & Imprints

Klonopin (11)

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses. Klonopin, a benzodiazepine, is used primarily as an anticonvulsant… View Drug & Imprints

Klor-con (9)

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The potassium ion is in the principle intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission… View Drug & Imprints

Kombiglyze Xr (6)

Kombiglyze Xr (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP -4) inhibitor class of drugs. FDA approved on July 31, 2009. Post-administration of kombiglyze xr, GLP-1 and GIP levels rise up to 2- to 3- fold. Because it is very selective of DPP-4 inhibition, there are fewer systemic side… View Drug & Imprints

Kytril (1)

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. Kytril is a selective inhibitor of type 3 serotonergic (5-HT3) receptors. Kytril has little or no affinity for other serotonin receptors, including 5-HT 1 , 5-HT 1A , 5-HT 1B/C , or 5-HT 2 ; for… View Drug & Imprints

Lamictal (17)

Lamictal is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamictal also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA )… View Drug & Imprints

Lansoprazole (29)

Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. It is manufactured by TAP Pharmaceutical Products. Lansoprazole has been marketed for many years and is one of several PPI’s available. Lansoprazole, an acid proton-pump inhibitor similar to omeprazole, is used as an untiulcer drug in the treatment and maintenance of healing… View Drug & Imprints

Lasix (10)

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. Lasix, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. Profound diuresis may cause fluid… View Drug & Imprints

Latuda (5)

Latuda is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA ) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. (Wikipedia) Latuda is a benzothiazol derivative that is an antagonist… View Drug & Imprints

Levaquin (3)

A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levaquin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levaquin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections,… View Drug & Imprints

Levothyroxine (149)

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell… View Drug & Imprints

Lexapro (3)

Lexapro, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of… View Drug & Imprints

Linzess (2)

Linzess is an orally administered, peptide agonist of guanylate cyclase 2C for the treatment of irritable bowel syndrome. Chemically, it is a heterodetic cyclic peptide and consists of fourteen amino acids. The protein sequence is as follows: Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr. There are three disulfide… View Drug & Imprints

Lipitor (8)

LCP -AtorFen is a fixed-dose combination therapy for the treatment of high cholesterol levels combining atorvastatin (the active ingredient of Lipitor®) and the lowest dose of fenofibrate without food effect. LCP -AtorFen is designed to be a once daily tablet offering a powerful and safe treatment of high cholesterol levels, addressing three primary cardiovascular risk… View Drug & Imprints

Lisinopril (152)

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE ), the enzyme responsible for the conversion of angiotensin I (ATI ) to angiotensin II (ATII ). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS ). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to… View Drug & Imprints

Lithium (33)

Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other… View Drug & Imprints

Loratadine (29)

Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. Loratadine is a long acting second generation antihistamine that is similar in structure to cyproheptadine and… View Drug & Imprints

Lorazepam (56)

A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. The most important clinical adverse… View Drug & Imprints

Lortab (8)

Narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant. Lortab, a semisynthetic opiate agonist and hydrogenated ketone derivative, is similar to other phenanthrene derivatives, such as codeine. Used as an analgesic, lortab is combined with acetaminophen, ibuprofen, or aspirin to treat pain. Used as… View Drug & Imprints

Losartan (111)

Losartan is an angiotensin-receptor blocker (ARB ) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS ); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood… View Drug & Imprints

Lunesta (3)

Lunesta, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic agent (viz., a sedative) used as a treatment for insomnia. Lunesta is the active stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrones. Its main selling point is that it is approved by the U.S. Food and Drug Administration… View Drug & Imprints

Lyrica (8)

Lyrica is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Lyrica is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as… View Drug & Imprints

Macrobid (2)

A bacteriostatic or bactericidal agent depending on the concentration and susceptibility of the infecting organism. Macrobid is active against some gram positive organisms such as S. aureus, S. epidermidis, S. saprophyticus, Enterococcus faecalis, S. agalactiae, group D streptococci, viridians streptococci and Corynebacterium. Its spectrum of activity against gram negative organisms includes E. coli, Enterobacter, Neisseria,… View Drug & Imprints

Meclizine (42)

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases… View Drug & Imprints

Meloxicam (41)

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID ) used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component. It is closely related to piroxicam. In Europe it is marketed under the brand names Movalis, Melox, and Recoxa. In North America it is generally marketed… View Drug & Imprints

Metformin (176)

Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM ). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. Use of metformin is associated with modest weight loss…. View Drug & Imprints

Methadone (17)

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is… View Drug & Imprints

Methocarbamol (19)

A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206) Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally… View Drug & Imprints

Methotrexate (11)

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA . Methotrexate is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine – which become the building blocks of DNA. They prevent these substances becoming incorporated… View Drug & Imprints

Methylphenidate (134)

A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Methylphenidate also blocks the reuptake… View Drug & Imprints

Methylprednisolone (23)

A prednisolone derivative with similar anti-inflammatory action. Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents. LD50=2000 mg/kg (orally in rat)

Metoclopramide (26)

A dopamine D2 antagonist that is used as an antiemetic. Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat… View Drug & Imprints

Metoprolol (81)

Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position… View Drug & Imprints

Metronidazole (27)

A nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed). Metronidazole, a synthetic… View Drug & Imprints

Mirtazapine (52)

Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. Mirtazapine has a tetracyclic chemical structure and is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is the only tetracyclic antidepressant that has been approved by the Food and Drug Administration to treat depression…. View Drug & Imprints

Mobic (4)

Mobic is a nonsteroidal anti-inflammatory drug (NSAID ) used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component. It is closely related to piroxicam. In Europe it is marketed under the brand names Movalis, Melox, and Recoxa. In North America it is generally marketed… View Drug & Imprints

Morphine (107)

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the… View Drug & Imprints

Motrin (21)

Motrin, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Motrin is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Motrin has pharmacologic actions similar to those of other prototypical NSAIAs, which are thought to act through inhibition of prostaglandin synthesis…. View Drug & Imprints

Mucinex (20)

An expectorant that also has some muscle relaxing action. It is used in many cough preparations. Mucinex is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that… View Drug & Imprints

Myrbetriq (2)

Myrbetriq is a beta-3 adrenergic receptor agonist for the management of overactive bladder. It is an alternative to antimuscarinic drugs for this indication. FDA approved on June 28, 2012. Myrbetriq has little effect on the mean maximum flow rate or mean detrusor pressure at maximum flow rate in patients with lower urinary tract symptoms and… View Drug & Imprints

Naloxone (11)

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. Naloxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone… View Drug & Imprints

Namenda (6)

Namenda is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is a noncompetitive NMDA receptor antagonist that binds preferentially to NMDA receptor-operated cation channels. It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. It is under investigation for the treatment of Alzheimer’s disease, but there has… View Drug & Imprints

Naprosyn (6)

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. Naprosyn is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naprosyn has analgesic and antipyretic properties. As with… View Drug & Imprints

Naproxen (134)

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. Naproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen has analgesic and antipyretic properties. As with… View Drug & Imprints

Neurontin (16)

Neurontin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, neurontin is widely used to relieve pain, especially neuropathic pain. Neurontin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized. Neurontin, an analog of GABA, is used as an anticonvulsant to… View Drug & Imprints

Nexium (5)

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H()-K()-ATPase (H()-K()-exchanging ATPase) in the proton pump of gastric parietal cells. Nexium is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing… View Drug & Imprints

Niacin (22)

A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP . It has pellagra-curative, vasodilating, and antilipemic properties. Niacin and niacinamide are indicated for prevention and treatment of vitamin B3 deficiency states. Vitamin B3 (Niacin) also acts… View Drug & Imprints

Niaspan (15)

A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP . It has pellagra-curative, vasodilating, and antilipemic properties. Niaspan and niaspanamide are indicated for prevention and treatment of vitamin B3 deficiency states. Vitamin B3 (Niaspan) also acts… View Drug & Imprints

Nicotine (23)

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular… View Drug & Imprints

Nifedipine (50)

Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the… View Drug & Imprints

Nitrofurantoin (28)

A bacteriostatic or bactericidal agent depending on the concentration and susceptibility of the infecting organism. Nitrofurantoin is active against some gram positive organisms such as S. aureus, S. epidermidis, S. saprophyticus, Enterococcus faecalis, S. agalactiae, group D streptococci, viridians streptococci and Corynebacterium. Its spectrum of activity against gram negative organisms includes E. coli, Enterobacter, Neisseria,… View Drug & Imprints

Norco (6)

Narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant. Norco, a semisynthetic opiate agonist and hydrogenated ketone derivative, is similar to other phenanthrene derivatives, such as codeine. Used as an analgesic, norco is combined with acetaminophen, ibuprofen, or aspirin to treat pain. Used as… View Drug & Imprints

Nortriptyline (39)

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA ). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts… View Drug & Imprints

Norvasc (6)

Norvasc is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, norvasc prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition… View Drug & Imprints

Nucynta (8)

Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008. Nucynta is a centrally-acting synthetic analgesic. It is 18 times less potent than morphine in terms of binding to human mu-opioid receptors. It also increases norepinephrine concentrations in the brains of rats via inhibition of norepinephrine reuptake. Selective mu-opioid antagonists… View Drug & Imprints

Nuedexta (1)

An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Nuedexta also blocks muscarinic and alpha-adrenergic neurotransmission. Nuedexta, a hydantoin anticonvulsant,… View Drug & Imprints

Nuvigil (4)

Nuvigil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA ), narcolepsy, or shift work disorder (SWD ). Research has shown that nuvigil significantly improves driving simulator performance in patients with SWD . Nuvigil consists of the… View Drug & Imprints

Omeprazole (50)

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. After oral administration,… View Drug & Imprints

Omnicef (1)

Omnicef (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA ) in December of 1997. Omnicef is a… View Drug & Imprints

Ondansetron (52)

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low… View Drug & Imprints

Onfi (6)

Onfi belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013…. View Drug & Imprints

Onglyza (2)

Onglyza (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP -4) inhibitor class of drugs. FDA approved on July 31, 2009. Post-administration of onglyza, GLP-1 and GIP levels rise up to 2- to 3- fold. Because it is very selective of DPP-4 inhibition, there are fewer systemic side effects. Onglyza… View Drug & Imprints

Opana (20)

An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092) Opana is… View Drug & Imprints

Opsumit (1)

Macitentan was approved in October 2013. It is indicated for patients with pulmonary arterial hypertension, and is marketed under the brand name Opsumit. Macitentan is an antagonist/blocker of endothelin receptors on blood vessels and smooth muscle, and, thus, blocks the stimulation of vasculature hypertrophy, inflammation, fibrosis, proliferation, and vasoconstriction. Similar to all drugs acting on… View Drug & Imprints

Orapred (3)

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Orapred is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Orapred is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic… View Drug & Imprints

Orkambi (1)

Orkambi is an experimental drug for the treatment of cystic fibrosis developed by Vertex Pharmaceuticals. The drug is designed to be effective in patients that have the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR ), the defective protein that causes the disease. F508del, meaning that the amino acid phenylalanine in position 508… View Drug & Imprints

Orlistat (1)

Orlistat is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free… View Drug & Imprints

Ortho Tri-cyclen (13)

Ortho Tri-cyclen is a form of progesterone, which is a female hormone important for the regulation of ovulation and menstruation. Ortho Tri-cyclen is used with estradiol to treat the symptoms of menopause. Ortho Tri-cyclen is used as a female contraceptive. Ortho Tri-cyclen is a progestin or a synthetic form of the naturally occurring female sex… View Drug & Imprints

Oseltamivir (3)

An acetamido cyclohexene that is a structural homolog of sialic acid and inhibits neuraminidase. Oseltamivir is an antiviral drug, a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B. Oseltamivir is a prodrug (usually administered as phosphate), it is hydrolysed hepatically to the active metabolite, the free carboxylate of… View Drug & Imprints

Osphena (1)

Osphena is a new selective non-hormonal estrogen receptor modulator (SERM ) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. The half maximal inhibitory concentration (IC50) for estrogen receptor (ER) alpha and beta are 0.8 μM and… View Drug & Imprints

Otezla (3)

Otezla is a novel, orally available small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE -4). It is indicated in the treatment of active psoriatic arthritis in adults (approved by the FDA in March 2014) and moderate to severe plaque psoriasis (approved by the FDA in September 2014). PDE -4 is a cyclic adenosine monophosphate… View Drug & Imprints

Oxybutynin (24)

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination, by decreasing muscle spasms of the bladder. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. Oxybutynin is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with… View Drug & Imprints

Oxycodone (158)

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette… View Drug & Imprints

Oxycontin (30)

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. Oxycontin, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycontin is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette… View Drug & Imprints

Paroxetine (56)

Paroxetine hydrochloride and paroxetine mesylate belong to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of… View Drug & Imprints

Paxil (14)

Paxil hydrochloride and paxil mesylate belong to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of… View Drug & Imprints

Percocet (7)

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. Percocet, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Percocet is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette… View Drug & Imprints

Phenergan (3)

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. Phenergan, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Phenergan is used as an antiemetic or to prevent motion sickness…. View Drug & Imprints

Phentermine (48)

A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. . Some common brand names for phentermine are Adipex-P® and Suprenza™. Phentermine is also available in combination medications such as Qsymia®. Phentermine is indicated in the management of… View Drug & Imprints

Phenytoin (24)

An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to… View Drug & Imprints

Plaquenil (1)

A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Plaquenil possesses antimalarial properties and also exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known. Symptoms of overdose include headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed… View Drug & Imprints

Plavix (2)

Plavix, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to inhibit blood clots in a variety of conditions such as peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Plavix is sold under the name Plavix by Sanofi and Bristol-Myers Squibb. The drug is an irreversible inhibitor of the P2Y12 adenosine diphosphate… View Drug & Imprints

potassium chloride (0)

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The potassium ion is in the principle intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission… View Drug & Imprints

Pradaxa (3)

Pradaxa is an oral prodrug that is metabolized by a serum esterase to dabigatran. It is a synthetic, competitive and reversible direct thrombin inhibitor. Inhibition of thrombin disrupts the coagulation cascade and inhibits the formation of clots. Pradaxa may be used to decrease the risk of venous thromboembolic events in patients who have undergone total… View Drug & Imprints

Pravastatin (57)

Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. It was derived from microbial transformation of mevastatin, the first statin discovered. It is a ring-opened dihydroxyacid with a 6’-hydroxyl group that does not require in vivo activation. Pravastatin is one of the lower potency statins; however, its increased hydrophilicity… View Drug & Imprints

Prednisone (46)

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has some mineralocorticoid activity and thus may affect ion exchange in the kidney.

Premarin (6)

Conjugated estrogens, a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. Conjugated estrogens, a mixture of the… View Drug & Imprints

Prilosec (9)

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. Prilosec belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. After oral administration,… View Drug & Imprints

Pristiq (3)

Pristiq (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin-norepinephrine reuptake inhibitor (SNRI class). Pristiq may be used to treat major depressive disorder and is being studied for use in the management of vasomotor symptoms in postmenopausal women. It is formulated as an extended release tablet. FDA approved in 2008. Pristiq… View Drug & Imprints

Promethazine (35)

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness…. View Drug & Imprints

Propranolol (98)

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is… View Drug & Imprints

Protonix (2)

Protonix is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Protonix is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis. Protonix is a proton pump inhibitor (PPI) that suppresses… View Drug & Imprints

Prozac (9)

Prozac hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Prozac is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks… View Drug & Imprints

Qsymia (4)

A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. . Some common brand names for qsymia are Adipex-P® and Suprenza™. Qsymia is also available in combination medications such as Qsymia®. Qsymia is indicated in the management of… View Drug & Imprints

Ramipril (63)

Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE ) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE , the enzyme responsible for the conversion of angiotensin I (ATI ) to angiotensin II (ATII ). ATII… View Drug & Imprints

Ranexa (8)

Ranexa is an antianginal medication. On January 31, 2006, ranexa was approved for use in the United States by the FDA for the treatment of chronic angina. Ranexa has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure. It is the first new anti-anginal developed in over 20… View Drug & Imprints

Ranitidine (46)

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach,… View Drug & Imprints

Reglan (16)

A dopamine D2 antagonist that is used as an antiemetic. Reglan, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Reglan is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Reglan may be used to treat… View Drug & Imprints

Relafen (2)

Relafen is a nonsteroidal anti-inflammatory drug (NSAID ) of the arylalkanoic acid family (which includes diclofenac). Marketed under the brand name Relafen, it has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAIDs. Relafen is a naphthylalkanone. Is is a non-selective prostaglandin G/H synthase (a.k.a. cyclooxygenase or… View Drug & Imprints

Relpax (2)

Relpax is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches. Relpax is a selective 5-hydroxytryptamine 1B/1D receptor agonist. In the anesthetized dog, relpax has been shown to reduce carotid arterial blood flow, with only a small increase in arterial blood pressure at high doses. While the effect on… View Drug & Imprints

Remeron (9)

Remeron is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. Remeron has a tetracyclic chemical structure and is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is the only tetracyclic antidepressant that has been approved by the Food and Drug Administration to treat depression…. View Drug & Imprints

Renvela (1)

Renvela is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. When taken with meals, renvela binds to dietary phosphate and prevents its absorption. It is marketed by Genzyme under the trade name Renagel. Patients with end-stage renal disease (ESRD) retain phosphorus and can develop hyperphosphatemia. High serum phosphorus can… View Drug & Imprints

Requip (12)

Requip is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson’s disease, and is also one of two medications in the United States with an FDA -approved indication for the treatment of restless legs syndrome (the other being Pramipexole). Requip is a nonergot dopamine agonist with high relative in… View Drug & Imprints

Restoril (7)

A benzodiazepine that acts as a gamma-aminobutyric acid modulator and anti-anxiety agent. Restoril is a benzodiazepine used as a hypnotic agent in the management of insomnia. Restoril produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Restoril increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to… View Drug & Imprints

Rexulti (6)

Rexulti is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM ), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. Rexulti is approved for the treatment of schizophrenia, and as an adjunctive treatment for major depressive disorder (MDD ). Although it failed Phase II… View Drug & Imprints

Risperdal (6)

Risperdal, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder. Risperdal is effective for treating the positive and negative symptoms of schizophrenia owing to… View Drug & Imprints

Risperidone (157)

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder. Risperidone is effective for treating the positive and negative symptoms of schizophrenia owing to… View Drug & Imprints

Ritalin (12)

A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. Ritalin is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Ritalin also blocks the reuptake… View Drug & Imprints

Robaxin (7)

A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206) Robaxin is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally… View Drug & Imprints

Saphris (3)

Developed by Schering-Plough after its merger with Organon International, saphris is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Saphris also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13,… View Drug & Imprints

Savella (4)

Savella is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. It more potently inhibits norepinephrine uptake than serotonin. It is provided as a racemic mixture. FDA approved in January 2009. Although savella prolongs the QTc interval, the increase is not considered clinically significant. LD50, oral, rat: 213 mg/kg. The most frequently occurring adverse reactions (≥… View Drug & Imprints

Senna (30)

Senna, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than… View Drug & Imprints

Sensipar (6)

Sensipar (INN ) is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. It is sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe…. View Drug & Imprints

Septra (3)

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the septra-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Septra resistance has been reported. Septra is… View Drug & Imprints

Seroquel (11)

Seroquel is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of seroquel is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha… View Drug & Imprints

Sertraline (67)

Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake…. View Drug & Imprints

Sildenafil (11)

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH ). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It… View Drug & Imprints

Simvastatin (76)

Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases… View Drug & Imprints

Singulair (6)

Singulair is a leukotriene receptor antagonist (LTRA ) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Singulair blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise… View Drug & Imprints

Skelaxin (2)

Skelaxin (marketed by King Pharmaceuticals under the brand name Skelaxin®) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately… View Drug & Imprints

Soma (5)

A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202) Soma is used as a skeletal muscle… View Drug & Imprints

Sonata (2)

Sonata is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Sonata interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Sonata is a schedule IV drug in the United States. Sonata is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for… View Drug & Imprints

Spiriva (1)

Spiriva is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD ). Spiriva is a muscarinic receptor antagonist, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect. Spiriva is a long–acting, antimuscarinic agent,… View Drug & Imprints

Spironolactone (30)

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead… View Drug & Imprints

Strattera (7)

Strattera is the first non-stimulant drug approved for the treatment of attention-deficit hyperactivity disorder (ADHD ). It is sold in the form of the hydrochloride salt of strattera. This chemical is manufactured and marketed under the brand name Strattera; by Eli Lilly and Company and as a generic Attentin by Torrent Pharmaceuticals. There is currently… View Drug & Imprints

Suboxone (8)

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. Suboxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Suboxone… View Drug & Imprints

Sudafed (12)

An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of… View Drug & Imprints

Synthroid (44)

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell… View Drug & Imprints

Tamoxifen (16)

One of the selective estrogen receptor modulators (SERM ) with tissue-specific activities for the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium. Tamoxifen belongs to a… View Drug & Imprints

Tamsulosin (12)

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of… View Drug & Imprints

Tegretol (7)

An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of phenytoin; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar. Tegretol, an anticonvulsant structurally similar to tricyclic antidepressants, is used to… View Drug & Imprints

Temazepam (32)

A benzodiazepine that acts as a gamma-aminobutyric acid modulator and anti-anxiety agent. Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to… View Drug & Imprints

Tenormin (6)

A cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect. Tenormin, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, tenormin differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing… View Drug & Imprints

Terazosin (28)

Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH ). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel… View Drug & Imprints

Testosterone (15)

Testosterone is a steroid sex hormone found in both men and women. In men, testosterone is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, promote physical and functional maturation of spermatozoa, maintain accessory organs of the male reproductive tract, support development of… View Drug & Imprints

Tetracycline (23)

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and… View Drug & Imprints

Tizanidine (35)

Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects… View Drug & Imprints

Topamax (10)

Topamax (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics, a division of Johnson & Johnson. It is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration… View Drug & Imprints

Toradol (1)

A pyrrolizine carboxylic acid derivative structurally related to indomethacin. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed) Toradol, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain. It is a peripherally acting analgesic. The biological activity… View Drug & Imprints

Tradjenta (1)

Tradjenta is a DPP -4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Two pharmacological characteristics that sets tradjenta apart from other DPP -4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011. Tradjenta is… View Drug & Imprints

Tramadol (58)

A narcotic analgesic proposed for moderate to severe pain. It may be habituating. Tramadol is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form. Tramadol, a centrally-acting analgesic,… View Drug & Imprints

Trazodone (41)

A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or… View Drug & Imprints

Triamcinolone (3)

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive… View Drug & Imprints

Triamterene (24)

A pteridine that is used as a mild diuretic. Triamterene, a relatively weak, potassium-sparing diuretic and antihypertensive, is used in the management of hypokalemia. Triamterene is similar in action to amiloride but, unlike amiloride, increases the urinary excretion of magnesium. In the event of overdosage it can be theorized that electrolyte imbalance would be the… View Drug & Imprints

Tricor (14)

An antilipemic agent which reduces both cholesterol and triglycerides in the blood. Tricor is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Tricor is also indicated as… View Drug & Imprints

Trileptal (4)

Trileptal is structurally a derivative of carbamazepine, adding an extra oxygen atom to the benzylcarboxamide group. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same… View Drug & Imprints

Truvada (1)

Truvada disoproxil fumarate (a prodrug of truvada), marketed by Gilead Sciences under the trade name Viread®, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV -infected people. In vivo truvada disoproxil fumarate is converted to truvada, an… View Drug & Imprints

Tylenol (50)

Tylenol, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Tylenol or Paracetamol is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and… View Drug & Imprints

Uceris (1)

Uceris is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Uceris is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R… View Drug & Imprints

Uloric (2)

Uloric is a xanathine oxidase (XO) inhibitor indicated in patients with gout suffering from hyperuricemia and is used in its chronic management. Uloric is not recommended for the treatment of asymptomatic hyperuricemia. Uloric is marketed under the trade name Uloric by Takeda Pharmaceuticals America, Inc., and was approved by the FDA in February 2009. Uloric… View Drug & Imprints

Ultracet (1)

A narcotic analgesic proposed for moderate to severe pain. It may be habituating. Ultracet is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form. Ultracet, a centrally-acting analgesic,… View Drug & Imprints

Ultram (13)

A narcotic analgesic proposed for moderate to severe pain. It may be habituating. Ultram is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form. Ultram, a centrally-acting analgesic,… View Drug & Imprints

Ultresa (3)

Ultresa is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Ultresa is marketed under several brand names such as Ultresa™ and Viokace™. Used in the treatment of cystic fibrosis or pancreatic dysfunction, ultresa helps improve fat digestion in the small intestine…. View Drug & Imprints

Uroxatral (1)

Uroxatral (INN , provided as the hydrochloride salt) is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH ). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. Uroxatral is a quinazoline-derivative alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, uroxatral is… View Drug & Imprints

Valacyclovir (24)

Valacyclovir (INN ) or valacyclovir (USAN ) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade name Valtrex or Zelitrex. Valacyclovir (INN) or Valacyclovir (USAN) is a prodrug and synthetic purine… View Drug & Imprints

Valium (6)

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and… View Drug & Imprints

Valtrex (4)

Valtrex (INN ) or valacyclovir (USAN ) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade name Valtrex or Zelitrex. Valtrex (INN) or Valacyclovir (USAN) is a prodrug and synthetic purine… View Drug & Imprints

Vancomycin (14)

Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. Vancomycin is a branched tricyclic glycosylated nonribosomal peptide produced by the fermentation of the Actinobacteria species Amycolatopsis orientalis (formerly Nocardia orientalis). It is often reserved as the “drug… View Drug & Imprints

Venlafaxine (95)

Venlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI ) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first… View Drug & Imprints

Ventolin (4)

Ventolin is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD . It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Ventolin is formulated as a racemic mixture of the R- and… View Drug & Imprints

Verapamil (76)

A calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias…. View Drug & Imprints

Vesicare (2)

Vesicare (rINN), marketed as vesicare succinate under the trade name Vesicare, is a urinary antispasmodic of the anticholinergic class. It is used in the treatment of overactive bladder with urge incontinence. Vesicare is a competitive muscarinic receptor antagonist. Muscarinic receptors play an important role in several major cholinergically mediated functions, including contractions of urinary bladder… View Drug & Imprints

Viagra (6)

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH ). Viagra elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It… View Drug & Imprints

Vicodin (6)

Narcotic analgesic related to codeine, but more potent and more addicting by weight. It is used also as cough suppressant. Vicodin, a semisynthetic opiate agonist and hydrogenated ketone derivative, is similar to other phenanthrene derivatives, such as codeine. Used as an analgesic, vicodin is combined with acetaminophen, ibuprofen, or aspirin to treat pain. Used as… View Drug & Imprints

Viibryd (3)

Viibryd is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT receptors. It has been shown to be equally efficacious as other antidepressants with similar gastrointestinal side effects and possibly with reduced sexual side effects and weight gain. Viibryd is an antidepressant agent that can used as an… View Drug & Imprints

Vimovo (2)

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H()-K()-ATPase (H()-K()-exchanging ATPase) in the proton pump of gastric parietal cells. Vimovo is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing… View Drug & Imprints

Vimpat (4)

Vimpat is a functionalized amino acid that has activity in the maximal electroshock seizure test, and is indicated for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Recent studies indicate that Vimpat only affects those neurons which are depolarized or active for long periods of time, typical of neurons at the focus of… View Drug & Imprints

Vistaril (6)

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. Vistaril, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine,… View Drug & Imprints

Voltaren (13)

A non-steroidal anti-inflammatory agent (NSAID ) with antipyretic and analgesic actions. It is primarily available as the sodium salt. Voltaren is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Voltaren is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis Symptoms of overdose include loss… View Drug & Imprints

Vytorin (4)

Vytorin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases… View Drug & Imprints

Vyvanse (13)

Vyvanse (L-lysine-d-amphetamine) is a prodrug of the psychostimulant d-amphetamine coupled with the essential amino acid L-lysine. It was developed so that the amphetamine psychostimulant is released and activated more slowly as the prodrug molecule is hydrolyzed consequently cleaving off the amino acid-during the first pass through the intestines and/or the liver. Amphetamines target the trace… View Drug & Imprints

Warfarin (116)

Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross… View Drug & Imprints

Wellbutrin (9)

A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. Wellbutrin, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin… View Drug & Imprints

Xalkori (2)

Xalkori an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC ). Verification of the presence of ALK fusion gene is done by Abbott Molecular’s Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.

Xanax (12)

A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA Drug Evaluations Annual, 1994, p238) Xanax, a benzodiazepine, is used to treat panic disorder and anxiety disorder. Unlike chlordiazepoxide, clorazepate, and prazepam, xanax has a shorter half-life… View Drug & Imprints

Xanax Xr (20)

A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA Drug Evaluations Annual, 1994, p238) Xanax Xr, a benzodiazepine, is used to treat panic disorder and anxiety disorder. Unlike chlordiazepoxide, clorazepate, and prazepam, xanax xr has a… View Drug & Imprints

Xarelto (3)

Xarelto is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet… View Drug & Imprints

Xeljanz (1)

Xeljanz is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate. Besides rheumatoid arthritis, xeljanz has… View Drug & Imprints

Xeloda (2)

Xeloda is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Xeloda is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. Xeloda is a fluoropyrimidine carbamate with antineoplastic activity indicated for the treatment of metastatic… View Drug & Imprints

Xenazine (2)

A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington’s disease. FDA approved on August 15, 2008. Prolongation of the QTc interval has been observed at doses of 50 mg. In… View Drug & Imprints

Xenical (4)

Xenical is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Xenical works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free… View Drug & Imprints

Xifaxan (2)

Xifaxan is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller’s diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as… View Drug & Imprints

Xigduo Xr (8)

Xigduo Xr is indicated for the management of diabetes mellitus type 2, and functions to improve glycemic control in adults when combined with diet and exercise. Xigduo Xr is a sodium-glucose cotransporter 2 inhibitor, which prevents glucose reabsorption in the kidney. Using xigduo xr leads to heavy glycosuria (glucose excretion in the urine), which can… View Drug & Imprints

Xtandi (2)

Xtandi is an androgen receptor inhibitor for the treatment of castration-resistant prostate cancer. FDA approved on August 31, 2012. Resitance to xtandi therapy has been observed. This may occurred due to an upregulation of NF-κB2/p52. The most common adverse reactions (≥ 5%) are asthenia/fatigue, back pain, diarrhea, arthralgia, hot flush, peripheral edema, musculoskeletal pain, headache,… View Drug & Imprints

Xyzal (1)

Xyzal is a third-generation non-sedative antihistamine indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis and uncomplicated skin manifestations of chronic idiopathic urticaria. It was developed from the second-generation antihistamine cetirizine. Xyzal is the R-enantiomer of the cetirizine racemate. Xyzal is an inverse agonist that decreases activity at histamine H1 receptors…. View Drug & Imprints

Yasmin (2)

Yasmin is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Yasmin differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of… View Drug & Imprints

Yaz (5)

Yaz is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Yaz differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of… View Drug & Imprints

Zanaflex (12)

Zanaflex is a short-acting drug for the management of spasticity. Zanaflex is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, zanaflex has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects… View Drug & Imprints

Zantac (11)

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. Zantac is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach,… View Drug & Imprints

Zestril (9)

Zestril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE ), the enzyme responsible for the conversion of angiotensin I (ATI ) to angiotensin II (ATII ). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS ). Zestril may be used to treat hypertension and symptomatic congestive heart failure, to… View Drug & Imprints

Zetia (2)

Zetia is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes. Zetia is in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption… View Drug & Imprints

Ziac (6)

Ziac is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Ziac is structurally similar to metoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to… View Drug & Imprints

Zithromax (8)

Zithromax is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, zithromax inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending… View Drug & Imprints

Zocor (14)

Zocor is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases… View Drug & Imprints

Zofran (4)

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. Zofran is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low… View Drug & Imprints

Zoloft (3)

Zoloft hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake…. View Drug & Imprints

Zolpidem (60)

Zolpidem is a prescription short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA ), an inhibitory neurotransmitter, by binding to benzodiazepine receptors which are located on the gamma-aminobutyric acid receptors. Zolpidem is used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). It is classified… View Drug & Imprints

Zomig (4)

Zomig is a synthetic tryptamine derivative and appears as a white powder that is readily soluble in water. Zomig is a selective agonist of serotonin (5-hydroxytryptamine; 5-HT) type 1B and 1D receptors. It is structurally and pharmacologically related to other selective 5-HT1B/1D receptor agonists, and has only a weak affinity for 5-HT1A, 5-HT5A, and 5-HT7… View Drug & Imprints

Zovirax (5)

A guanosine analog antiviral drug that acts as an antimetabolite. Zovirax is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles). Zovirax has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. Currently approved drugs for the treatment of herpes labialis (cold sores)… View Drug & Imprints

Zubsolv (5)

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. Zubsolv is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Zubsolv… View Drug & Imprints

Zyprexa (10)

Zyprexa is an atypical antipsychotic, approved by the FDA in 1996. Zyprexa is manufactured and marketed by the pharmaceutical company Eli Lilly and Company, whose patent for zyprexa proper ends in 2011. Zyprexa, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and… View Drug & Imprints

Zyrtec (7)

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. Zyrtec, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic… View Drug & Imprints

Zytiga (1)

Zytiga is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Zytiga is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than zytiga itself. FDA approved on April 28, 2011. Zytiga is associated with… View Drug & Imprints

Zyvox (2)

Zyvox is a synthetic antibiotic, the first of the oxazolidinone class, used for the treatment of infections caused by multi-resistant bacteria including streptococcus and methicillin-resistant Staphylococcus aureus (MRSA ). The drug works by inhibiting the initiation of bacterial protein synthesis. Zyvox is a synthetic antibacterial agent of a new class of antibiotics, the oxazolidinones, which… View Drug & Imprints

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