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Acetaminophen

Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.

Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. At therapeutic doses acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, kidney function, or the fetal ductus arteriosus (as NSAIDs can). Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way. Acetaminophen and NSAIDs have the benefit of being completely free of problems with addiction, dependence, tolerance and withdrawal. Acetaminophen is used on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone.

Oral, mouse: LD50 = 338 mg/kg; Oral, rat: LD50 = 1944 mg/kg. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with glucuronic acid and, to a lesser extent, sulfuric acid. Conjugates are then excreted by the kidneys. Only a small portion is excreted in unchanged in urine or oxidized via the hepatic cytochrome P450 enzyme system (CYP2E1). Metabolism via CYP2E1 produces a toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). The toxic effects of acetaminophen are due to NAPQI, not acetaminophen itself nor any of the major metabolites. At therapeutic doses, NAPQI reacts with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is excreted by the kidneys. High doses of acetaminophen may cause glutathione depletion, accumulation of NAPQI and hepatic necrosis. The maximum daily dose of acetaminophen is 4 g. Liver failure has been observed at doses as low as 6 g per day. As such, the maximum daily and single dose of acetaminophen is currently being reviewed in some countries. N-acetyl-cysteine, a precursor of glutathione, may be administered in the event of acetaminophen toxicity.

Imprints


Drug: Acetaminophen
Strength: 500mg
Pill Imprint: L484
Color: White
Shape: Capsule-shape

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Drug: Acetaminophen
Strength: 500 Mg
Pill Imprint: 44 175
Color: White
Shape: Elliptical / Oval

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Drug: Acetaminophen
Strength: 500 Mg
Pill Imprint: L 5
Color: Blue / Red
Shape: Capsule-shape

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Drug: Acetaminophen
Strength: 500 Mg
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Drug: Acetaminophen
Strength: 500 Mg
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Drug: Acetaminophen
Strength: 500 Mg
Pill Imprint: GPI A5
Color: White
Shape: Capsule-shape

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Drug: Acetaminophen
Strength: 325 Mg
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Drug: Acetaminophen
Strength: 500 Mg
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Drug: Acetaminophen
Strength: 325 Mg
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Drug: Acetaminophen
Strength: 500 Mg
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Color: White
Shape: Elliptical / Oval

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Drug: Acetaminophen
Strength: 500 Mg
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Color: White
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Drug: Acetaminophen
Strength: 325 Mg
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Color: White
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Drug: Acetaminophen
Strength: 500 Mg
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Color: Red
Shape: Round

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Drug: Acetaminophen
Strength: 325 Mg
Pill Imprint: L403 325 MG
Color: White
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Drug: Acetaminophen
Strength: 500 Mg
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Color: White
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Drug: Acetaminophen
Strength: 500 Mg
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Strength: 500 Mg
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Shape: Capsule-shape

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Strength: 500 Mg
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Drug: Acetaminophen
Strength: 500 Mg
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Drug: Acetaminophen
Strength: 325 Mg
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Strength: 325 Mg
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Strength: 325 Mg
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Drug: Acetaminophen
Strength: 325 Mg
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Drug: Acetaminophen
Strength: 500 Mg
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Strength: 500 Mg
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Drug: Acetaminophen
Strength: 500 Mg
Pill Imprint: TCL 341
Color: White
Shape: Capsule-shape

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Drug: Acetaminophen
Strength: 500 Mg
Pill Imprint: K10
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Shape: Capsule-shape

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Strength: 325 Mg
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Drug: Acetaminophen
Strength: 500 Mg
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Drug: Acetaminophen
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Strength: 500 Mg
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Drug: Acetaminophen
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Strength: 500 Mg
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Strength: 500 Mg
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Strength: 500 Mg
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Color: Red / Gray
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Strength: 500 Mg
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Strength: 500 Mg
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Drug: Acetaminophen
Strength: 650 Mg
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Color: White
Shape: Elliptical / Oval

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Drug: Acetaminophen
Strength: 500 Mg
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Color: White
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Drug: Acetaminophen
Strength: 325 Mg
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Strength: 500 Mg
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Drug: Acetaminophen
Strength: 325 Mg
Pill Imprint: 44 240
Color: White
Shape: Capsule-shape

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Drug: Acetaminophen
Strength: 500 Mg
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Color: White
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Strength: 500 Mg
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Color: Red
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Strength: 500 Mg
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Drug: Acetaminophen
Strength: 325 Mg
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Color: White
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Drug: Acetaminophen
Strength: Acetaminophen 500 Mg
Pill Imprint: 44 148
Color: White
Shape: Round

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Drug: Acetaminophen
Strength: 500 Mg
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Strength: 500 Mg
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Color: White
Shape: Capsule-shape

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Strength: Acetaminophen 500 Mg
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Strength: 80 Mg
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Strength: 500 Mg
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Shape: Elliptical / Oval

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Strength: Acetaminophen 500 Mg
Pill Imprint: PH 044
Color: White
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Strength: 325 Mg
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Drug: Acetaminophen
Strength: 80 Mg
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Strength: Acetaminophen 325 Mg
Pill Imprint: PH 020
Color: White
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Strength: 500 Mg
Pill Imprint: L-5
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Shape: Capsule-shape

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Strength: Acetaminophen 325 Mg
Pill Imprint: Help H
Color: White
Shape: Elliptical / Oval

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Strength: 500 Mg
Pill Imprint: CFNX
Color: White
Shape: Elliptical / Oval

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Drug: Acetaminophen
Strength: 500 Mg
Pill Imprint: 9239M 500
Color: White
Shape: Capsule-shape

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Drug: Acetaminophen
Strength: Acetaminophen 500 Mg
Pill Imprint: CRX
Color: Red
Shape: Elliptical / Oval

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Drug: Acetaminophen
Strength: 80 Mg
Pill Imprint: TY 80
Color: Pink
Shape: Round

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Drug: Acetaminophen
Strength: 80 Mg
Pill Imprint: TY 80
Color: Purple
Shape: Round

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