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Amitriptyline

Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA ). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).

Amitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is extremely sedating, and thus improvement of sleep patterns can be the first benefit of treatment. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and conduction, and a lowering of the seizure threshold. As with other antidepressants, several weeks of therapy may be required in order to realize the full clinical benefit of amitriptyline. Although not a labelled indication, amitriptyline is widely used in the management of chronic nonmalignant pain (e.g., post-herpetic neuralgia, fibromyalgia).

LD50=350 mg/kg (in mice). Symptoms of overdose include abnormally low blood pressure, confusion, convulsions, dilated pupils and other eye problems, disturbed concentration, drowsiness, hallucinations, impaired heart function, rapid or irregular heartbeat, reduced body temperature, stupor, and unresponsiveness or coma. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

Imprints


Drug: Amitriptyline
Strength: 25 Mg
Pill Imprint: M 51
Color: Green
Shape: Round

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Drug: Amitriptyline
Strength: 25 Mg
Pill Imprint: V 2102
Color: Yellow
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Drug: Amitriptyline
Strength: 10 Mg
Pill Imprint: 2101 V
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Drug: Amitriptyline
Strength: 50 Mg
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Drug: Amitriptyline
Strength: 25 Mg
Pill Imprint: GG 44
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Drug: Amitriptyline
Strength: 10 Mg
Pill Imprint: M77
Color: White
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Drug: Amitriptyline
Strength: 50 Mg
Pill Imprint: M 36
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Drug: Amitriptyline
Strength: 100 Mg
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Drug: Amitriptyline
Strength: 50 Mg
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Drug: Amitriptyline
Strength: 10 Mg
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Drug: Amitriptyline
Strength: 100 Mg
Pill Imprint: 2105 V
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Drug: Amitriptyline
Strength: 75 Mg
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Drug: Amitriptyline
Strength: 75 Mg
Pill Imprint: M 37
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Drug: Amitriptyline
Strength: 150 Mg
Pill Imprint: M 39
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Shape: Capsule-shape

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Drug: Amitriptyline
Strength: 150 Mg
Pill Imprint: V 2106
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Drug: Amitriptyline
Strength: 100 Mg
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Color: Orange
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Drug: Amitriptyline
Strength: 25 Mg
Pill Imprint: MP 25
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Drug: Amitriptyline
Strength: 75 Mg
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Drug: Amitriptyline
Strength: 10 Mg
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Drug: Amitriptyline
Strength: 25 Mg
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Strength: 50 Mg
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Drug: Amitriptyline
Strength: 150 Mg
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Color: Green
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Drug: Amitriptyline
Strength: 50 Mg
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Drug: Amitriptyline
Strength: 25 MG
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Drug: Amitriptyline
Strength: 10 Mg
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Drug: Amitriptyline
Strength: 75 Mg
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Drug: Amitriptyline
Strength: 10 Mg
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Drug: Amitriptyline
Strength: 100 Mg
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Color: Orange
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Drug: Amitriptyline
Strength: 100 MG
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Drug: Amitriptyline
Strength: 50 MG
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Drug: Amitriptyline
Strength: 75 MG
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Drug: Amitriptyline
Strength: 75 Mg
Pill Imprint: SL 369
Color: Purple
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Drug: Amitriptyline
Strength: 100 Mg
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Color: Orange
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Drug: Amitriptyline
Strength: 150 Mg
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Drug: Amitriptyline
Strength: 150 MG
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Color: Pink
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Strength: 150 MG
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Strength: 10 Mg
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Strength: 10 Mg / 2 Mg
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Strength: 25 Mg / 10 Mg
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Strength: 50 Mg / 4 Mg
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Drug: Amitriptyline
Strength: 12.5 Mg / 5 Mg
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Strength: 25 Mg / 2 Mg
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Drug: Amitriptyline
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Strength: 10 Mg / 4 Mg
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Drug: Amitriptyline
Strength: 10 Mg / 2 Mg
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Drug: Amitriptyline
Strength: 50 Mg / 4 Mg
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Drug: Amitriptyline
Strength: 25 Mg / 4 Mg
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Drug: Amitriptyline
Strength: 10 Mg / 25 Mg
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Drug: Amitriptyline
Strength: 5 Mg / 12.5 Mg
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Drug: Amitriptyline
Strength: 10 Mg
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Drug: Amitriptyline
Strength: 25 Mg
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Drug: Amitriptyline
Strength: 50 Mg
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Strength: 75 Mg
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Drug: Amitriptyline
Strength: 100 Mg
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Drug: Amitriptyline
Strength: 150 Mg
Pill Imprint: I6
Color: Brown
Shape: Capsule-shape

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Drug: Amitriptyline
Strength: 25 MG
Pill Imprint: ELAVIL STUART 45
Color: Yellow
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Drug: Amitriptyline
Strength: 10 Mg
Pill Imprint: ELAVIL 40
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Drug: Amitriptyline
Strength: 50 MG
Pill Imprint: ELAVIL STUART 41
Color: Tan
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Drug: Amitriptyline
Strength: 150 MG
Pill Imprint: ELAVIL STUART 47
Color: Blue
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Drug: Amitriptyline
Strength: 25 Mg
Pill Imprint: ELAVIL 45
Color: Yellow
Shape: Round

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Drug: Amitriptyline
Strength: 75 MG
Pill Imprint: ENDEP 75 ROCHE
Color: Yellow
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Drug: Amitriptyline
Strength: 10 MG
Pill Imprint: ELAVIL STUART 40
Color: Blue
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Strength: 100 Mg
Pill Imprint: ELAVIL 43
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Drug: Amitriptyline
Strength: 75 MG
Pill Imprint: ELAVIL STUART 42
Color: Orange
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Drug: Amitriptyline
Strength: 100 MG
Pill Imprint: ELAVIL STUART 43
Color: Purple
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Drug: Amitriptyline
Strength: 150 MG
Pill Imprint: ENDEP 150 ROCHE
Color: Red
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Drug: Amitriptyline
Strength: 100 MG
Pill Imprint: ENDEP 100 ROCHE
Color: Pink
Shape: Round

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Drug: Amitriptyline
Strength: 10 MG
Pill Imprint: ENDEP 10 ROCHE
Color: Yellow
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Drug: Amitriptyline
Strength: 25 MG
Pill Imprint: ENDEP 25 ROCHE
Color: Yellow
Shape: Round

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Drug: Amitriptyline
Strength: 50 MG
Pill Imprint: ENDEP 50 ROCHE
Color: Yellow
Shape: Round

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