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Amlodipine

Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina.

Amlodipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. There are at least five different types of calcium channels in Homo sapiens: L-, N-, P/Q-, R- and T-type. It was widely accepted that DHP CCBs target L-type calcium channels, the major channel in muscle cells that mediate contraction; however, some studies have indicated that amlodipine also binds to and inhibits N-type calcium channels (see references in Targets section). Similar to other DHP CCBs, amlodipine binds directly to inactive L-type calcium channels stabilizing their inactive conformation. Since arterial smooth muscle depolarizations are longer in duration than cardiac muscle depolarizations, inactive channels are more prevalent in smooth muscle cells. Alternative splicing of the alpha-1 subunit of the channel gives amlodipine additional arterial selectivity. At therapeutic sub-toxic concentrations, amlodipine has little effect on cardiac myocytes and conduction cells.

Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.

Imprints


Drug: Amlodipine
Strength: 5 Mg
Pill Imprint: M A9
Color: Blue
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Drug: Amlodipine
Strength: 10 Mg
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
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Drug: Amlodipine
Strength: 2.5 Mg
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Drug: Amlodipine
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Drug: Amlodipine
Strength: 2.5 Mg
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Drug: Amlodipine
Strength: 5 Mg
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Drug: Amlodipine
Strength: 10 Mg
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Drug: Amlodipine
Strength: 2.5 Mg
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Drug: Amlodipine
Strength: 2.5 Mg
Pill Imprint: E 55
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Drug: Amlodipine
Strength: 5 Mg / 10 Mg
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Drug: Amlodipine
Strength: 5 Mg / 20 Mg
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Drug: Amlodipine
Strength: 10 Mg / 20 Mg
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Drug: Amlodipine
Strength: 5 Mg
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Drug: Amlodipine
Strength: 5 Mg / 10 Mg
Pill Imprint: 930 Par
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Drug: Amlodipine
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Drug: Amlodipine
Strength: 10 Mg / 20 Mg
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Strength: 5 Mg / 20 Mg
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Drug: Amlodipine
Strength: 5 Mg / 20 Mg
Pill Imprint: > AB 3
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Drug: Amlodipine
Strength: 5 Mg / 20 Mg
Pill Imprint: 931 Par
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Drug: Amlodipine
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Pill Imprint: TEVA 7373
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Drug: Amlodipine
Strength: 10 Mg / 20 Mg
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Drug: Amlodipine
Strength: 10 Mg / 40 Mg
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Drug: Amlodipine
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Strength: 5 Mg / 40 Mg
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Drug: Amlodipine
Strength: 5 Mg / 20 Mg
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Color: Purple / Peach
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Drug: Amlodipine
Strength: 10 Mg / 40 Mg
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Color: Blue
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: RDY 338
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: 93 7370 93 7370
Color: White
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Drug: Amlodipine
Strength: 5 Mg / 10 Mg
Pill Imprint: > AB 2
Color: White
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: S SANDOZ 571
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Drug: Amlodipine
Strength: 10 Mg / 40 Mg
Pill Imprint: > AB 6
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Strength: 10 Mg / 40 Mg
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Drug: Amlodipine
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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
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Color: Blue
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: TEVA 7370
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Drug: Amlodipine
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Drug: Amlodipine
Strength: 5 Mg / 20 Mg
Pill Imprint: LOTREL 2265
Color: Pink
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: 929 Par
Color: Green
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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
Pill Imprint: > AB 5
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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
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Color: Blue / Pink
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: > AB 1
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Drug: Amlodipine
Strength: 2.5 Mg
Pill Imprint: 568
Color: White
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Drug: Amlodipine
Strength: 5 Mg
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Drug: Amlodipine
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Pill Imprint: MYLAN 6895 MYLAN 6895
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Drug: Amlodipine
Strength: 10 Mg
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Drug: Amlodipine
Strength: 5 Mg
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Drug: Amlodipine
Strength: 2.5 Mg
Pill Imprint: C 126
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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: TV J2
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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
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Drug: Amlodipine
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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: N 83
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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
Pill Imprint: N 82
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Drug: Amlodipine
Strength: 5 Mg / 320 Mg
Pill Imprint: N 81
Color: White
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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
Pill Imprint: N 08
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Drug: Amlodipine
Strength: 10 Mg
Pill Imprint: 10 Mg
Color: White
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: I 96
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Drug: Amlodipine
Strength: 5 Mg
Pill Imprint: 5 Mg
Color: White
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Drug: Amlodipine
Strength: 2.5 Mg
Pill Imprint: A
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Pill Imprint: S SANDOZ 577
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Drug: Amlodipine
Strength: 10 Mg
Pill Imprint: A10
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Drug: Amlodipine
Strength: 10 Mg
Pill Imprint: ML 23
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Drug: Amlodipine
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Pill Imprint: I 98
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Drug: Amlodipine
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Drug: Amlodipine
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Pill Imprint: J 03
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Drug: Amlodipine
Strength: 10 Mg
Pill Imprint: 570
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Drug: Amlodipine
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Pill Imprint: J 02
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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
Pill Imprint: J 01
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Drug: Amlodipine
Strength: 5 Mg
Pill Imprint: ML 22
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Drug: Amlodipine
Strength: 2.5 Mg
Pill Imprint: ADP Bes 2.5
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Drug: Amlodipine
Strength: 5 Mg
Pill Imprint: A5
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Drug: Amlodipine
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Pill Imprint: ADP Bes 10
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Drug: Amlodipine
Strength: 5 Mg
Pill Imprint: ADP Bes 5
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Drug: Amlodipine
Strength: 10 Mg / 40 Mg
Pill Imprint: LU C55
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Drug: Amlodipine
Strength: 2.5 Mg
Pill Imprint: U 241
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Drug: Amlodipine
Strength: 10 Mg
Pill Imprint: U 243
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Drug: Amlodipine
Strength: 5 Mg / 80 Mg
Pill Imprint: LU C56
Color: Red & White
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Drug: Amlodipine
Strength: 10 Mg / 40 Mg
Pill Imprint: 1345
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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
Pill Imprint: LU C54
Color: White & Yellow
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Drug: Amlodipine
Strength: 10 Mg / 80 Mg
Pill Imprint: LU C57
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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
Pill Imprint: 1346
Color: Gray & White
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Drug: Amlodipine
Strength: 5 Mg / 80 Mg
Pill Imprint: 1344
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Drug: Amlodipine
Strength: 5 Mg
Pill Imprint: U 242
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Drug: Amlodipine
Strength: 10 Mg / 80 Mg
Pill Imprint: 1343
Color: Gray & White
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Drug: Amlodipine
Strength: 2.5 Mg / 10 Mg
Pill Imprint: APO 2.5/10
Color: White
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Drug: Amlodipine
Strength: 5 Mg / 10 Mg
Pill Imprint: APO 5/10
Color: Brown
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 20 Mg
Pill Imprint: APO 5/20
Color: Pink
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
Pill Imprint: APO 5/40
Color: Blue
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Drug: Amlodipine
Strength: 10 Mg / 20 Mg
Pill Imprint: APO 10/20
Color: Purple
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Drug: Amlodipine
Strength: 10 Mg / 40 Mg
Pill Imprint: APO 10/40
Color: Blue
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 40 Mg
Pill Imprint: TA1M
Color: Blue & White
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Drug: Amlodipine
Strength: 10 Mg / 40 Mg
Pill Imprint: TA2M
Color: Blue & White
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Drug: Amlodipine
Strength: 5 Mg / 80 Mg
Pill Imprint: TA3M
Color: Blue & White
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Drug: Amlodipine
Strength: 10 Mg / 80 Mg
Pill Imprint: TA4M
Color: Blue & White
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: P 574
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
Pill Imprint: P 575
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 320 Mg
Pill Imprint: P 576
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
Pill Imprint: P 577
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: L298
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
Pill Imprint: L300
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 320 Mg
Pill Imprint: L299
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
Pill Imprint: L301
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: LU Q12
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
Pill Imprint: LU Q14
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 320 Mg
Pill Imprint: LU Q13
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
Pill Imprint: LU Q15
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: MX1
Color: Peach
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
Pill Imprint: MX2
Color: Tan
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 320 Mg
Pill Imprint: MX43
Color: Orange
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
Pill Imprint: MX44
Color: Peach
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: 1207
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
Pill Imprint: 1206
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 320 Mg
Pill Imprint: 1205
Color: Brown
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
Pill Imprint: 1204
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 160 Mg
Pill Imprint: NVR ECE
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 160 Mg
Pill Imprint: NVR UIC
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 320 Mg
Pill Imprint: NVR CSF
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 320 Mg
Pill Imprint: NVR LUF
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 25 Mg / 160 Mg
Pill Imprint: TV 7037
Color: Yellow
Shape: Round

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Drug: Amlodipine
Strength: 10 Mg / 12.5 Mg / 160 Mg
Pill Imprint: TV 7810
Color: Yellow
Shape: Round

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 160 Mg
Pill Imprint: TV 7038
Color: Brown
Shape: Round

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 320 Mg
Pill Imprint: TV 7809
Color: Brown
Shape: Round

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Drug: Amlodipine
Strength: 5 Mg / 12.5 Mg / 160 Mg
Pill Imprint: NVR VCL
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 12.5 Mg / 160 Mg
Pill Imprint: NVR VDL
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 25 Mg / 160 Mg
Pill Imprint: NVR VEL
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 160 Mg
Pill Imprint: NVR VHL
Color: Brown
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 320 Mg
Pill Imprint: NVR VFL
Color: Brown
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 12.5 Mg / 160 Mg
Pill Imprint: P 172
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 12.5 Mg / 160 Mg
Pill Imprint: P 174
Color: Brown
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 25 Mg / 160 Mg
Pill Imprint: P 173
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 160 Mg
Pill Imprint: P 185
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 320 Mg
Pill Imprint: P 175
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 12.5 Mg / 160 Mg
Pill Imprint: LU W41
Color: White
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 12.5 Mg / 160 Mg
Pill Imprint: LU W43
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 25 Mg / 160 Mg
Pill Imprint: LU W42
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 160 Mg
Pill Imprint: LU W44
Color: Beige
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 320 Mg
Pill Imprint: LU W45
Color: Red
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 5 Mg / 12.5 Mg / 160 Mg
Pill Imprint: 1326
Color: White
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 10 Mg / 12.5 Mg / 160 Mg
Pill Imprint: 1327
Color: Yellow
Shape: Elliptical / Oval

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Drug: Amlodipine
Strength: 5 Mg / 25 Mg / 160 Mg
Pill Imprint: 1329
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 160 Mg
Pill Imprint: 1328
Color: Yellow
Shape: Capsule-shape

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Drug: Amlodipine
Strength: 10 Mg / 25 Mg / 320 Mg
Pill Imprint: 1325
Color: Yellow
Shape: Capsule-shape

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