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Baclofen

Baclofen is a gamma-amino-butyric acid (GABA ) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA -B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.

Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)

Imprints


Drug: Baclofen
Strength: 10 Mg
Pill Imprint: V 22 65
Color: White
Shape: Elliptical / Oval

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: BAC 10 832
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: 10 Z 4096
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: TV 4096
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: N029
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: V 22 66
Color: White
Shape: Elliptical / Oval

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: 832 BC 20
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: TV 4097
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: 10 DAN 5730
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: Z 4097 20
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: N030
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: 291
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: BN 10 G
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: 20 DAN 5731
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: 292
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: MX 23
Color: Yellow
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: MX 24
Color: Yellow
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: LCI 1330
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: BN 20 G
Color: White
Shape: Round

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Drug: Baclofen
Strength: 20 Mg
Pill Imprint: LCI 1337
Color: White
Shape: Round

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Drug: Baclofen
Strength: 10 Mg
Pill Imprint: 686/10 WATSON
Color: White
Shape: Elliptical / Oval

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Drug: Baclofen
Strength: 10 MG
Pill Imprint: 10 10 LIORESAL
Color: White
Shape: Elliptical / Oval

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