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Biaxin

Biaxin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Biaxin may be bacteriostatic or bactericidal depending on the organism and drug concentration.

Biaxin is a macrolide antibiotic whose spectrum of activity includes many gram-positive (Staphylococcus aureus, S. pneumoniae, and S. pyogenes) and gram-negative aerobic bacteria (Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis), many anaerobic bacteria, some mycobacteria, and some other organisms including Mycoplasma, Ureaplasma, Chlamydia, Toxoplasma, and Borrelia. Other aerobic bacteria that biaxin has activity against include C. pneumoniae and M. pneumoniae. Biaxin has an in-vitro activity that is similar or greater than that of erythromycin against erythromycin-susceptible organisms. Biaxin is usually bacteriostatic, but may be bactericidal depending on the organism and the drug concentration.

Symptoms of toxicity include diarrhea, nausea, abnormal taste, dyspepsia, and abdominal discomfort. Transient hearing loss with high doses has been observed. Pseudomembraneous colitis has been reported with biaxin use. Allergic reactions ranging from urticaria and mild skin eruptions to rare cases of anaphylaxis and Stevens-Johnson syndrome have also occurred. Rare cases of severe hepatic dysfunctions also have been reported. Hepatic failure is usually reversible, but fatalities have been reported. Biaxin may also cause tooth decolouration which may be removed by dental cleaning. Fetal abnormalities, such as cardiovascular defects, cleft palate and fetal growth retardation, have been observed in animals. Biaxin may cause QT prolongation.

Imprints


Drug: Biaxin
Strength: 500 Mg
Pill Imprint: A KL
Color: Yellow
Shape: Elliptical / Oval

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Drug: Biaxin
Strength: 250 Mg
Pill Imprint: A KT
Color: Yellow
Shape: Elliptical / Oval

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