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Bisoprolol

Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Bisoprolol is structurally similar to metoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At lower doses (less than 20 mg daily), bisoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with daily doses of 20 mg or greater. Unlike propranolol and pindolol, bisoprolol does not exhibit membrane-stabilizing or sympathomimetic activity. Bisoprolol possesses a single chiral centre and is administered as a racemic mixture. Only l-bisoprolol exhibits significant β-blocking activity.

Bisoprolol is a competitive, cardioselective β1-adrenergic antagonist. Activation of β1-receptors (located mainly in the heart) by epinephrine increases heart rate and the blood pressure causing the heart to consume more oxygen. β1-adrenergic blocking agents such as bisopolol lower the heart rate and blood pressure and may be used to reduce workload on the heart and hence oxygen demands. They are routinely prescribed in patients with ischemic heart disease. In addition, β1-selective blockers prevent the release of renin, a hormone produced by the kidneys causes constriction of blood vessels. Bisoprolol is lipophilic and exhibits no intrinsic sympathomimetic activity (ISA) or membrane-stabilizing activity.

Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.

Imprints


Drug: Bisoprolol
Strength: 10 Mg
Pill Imprint: M 524
Color: White
Shape: Round

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Drug: Bisoprolol
Strength: 5 Mg
Pill Imprint: E 771
Color: Pink
Shape: Round

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Drug: Bisoprolol
Strength: 5 Mg
Pill Imprint: M 523
Color: Pink
Shape: Round

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Drug: Bisoprolol
Strength: 5 Mg
Pill Imprint: UL 5 5
Color: Pink
Shape: Round

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Drug: Bisoprolol
Strength: 10 Mg
Pill Imprint: UL 10
Color: White
Shape: Round

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Drug: Bisoprolol
Strength: 10 Mg
Pill Imprint: E 774
Color: White
Shape: Round

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Drug: Bisoprolol
Strength: 5 Mg
Pill Imprint: C 86
Color: Pink
Shape: Round

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Drug: Bisoprolol
Strength: 5 Mg
Pill Imprint: 5270 93
Color: Pink
Shape: Round

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Drug: Bisoprolol
Strength: 10 Mg
Pill Imprint: C 87
Color: White
Shape: Round

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Drug: Bisoprolol
Strength: 10 Mg
Pill Imprint: 5271 93
Color: White
Shape: Round

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Drug: Bisoprolol
Strength: 5 Mg
Pill Imprint: B 1 L L
Color: Pink
Shape: Heart-shape

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Drug: Bisoprolol
Strength: 5 Mg
Pill Imprint: B B 6 0
Color: Pink
Shape: Heart-shape

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Drug: Bisoprolol
Strength: 10 Mg
Pill Imprint: L L B 3
Color: White
Shape: Heart-shape

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Drug: Bisoprolol
Strength: 10 Mg
Pill Imprint: B 61
Color: White
Shape: Heart-shape

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