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Diovan

Diovan is an angiotensin-receptor blocker (ARB ) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Diovan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS ); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE ) inhibitors, ARBs do not have the adverse effect of dry cough. Diovan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.

Diovan belongs to a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Diovan is a specific and selective type-1 angiotensin II receptor (AT1) antagonist which blocks the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS). RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering cardiovascular structure. Angiotensin II binds to two receptors: AT1 and type-2 angiotensin II receptor (AT2). AT1 is a G-protein coupled receptor (GPCR) that mediates the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Studies performed in recent years suggest that AT2 antagonizes AT1-mediated effects and directly affects long-term blood pressure control by inducing vasorelaxation and increasing urinary sodium excretion. Angiotensin receptor blockers (ARBs) are non-peptide competitive inhibitors of AT1. ARBs block the ability of angiotensin II to stimulate pressor and cell proliferative effects. Unlike ACE inhibitors, ARBs do not affect bradykinin-induced vasodilation. The overall effect of ARBs is a decrease in blood pressure.

Imprints


Drug: Diovan
Strength: 160 Mg
Pill Imprint: NVR DX
Color: Orange
Shape: Egg-shape

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Drug: Diovan
Strength: 80 Mg
Pill Imprint: NVR DV
Color: Red
Shape: Egg-shape

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Drug: Diovan
Strength: 320 Mg
Pill Imprint: NVR DXL
Color: Purple
Shape: Egg-shape

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Drug: Diovan
Strength: 40 Mg
Pill Imprint: NVR D O
Color: Yellow
Shape: Elliptical / Oval

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Drug: Diovan
Strength: 40 Mg
Pill Imprint: NVR DO
Color: Yellow
Shape: Round

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Drug: Diovan
Strength: 160 Mg
Pill Imprint: CG GOG
Color: Gray / Pink
Shape: Capsule-shape

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Drug: Diovan
Strength: 80 Mg
Pill Imprint: CG FZF
Color: Gray / Pink
Shape: Capsule-shape

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