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Diphenhydramine

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

Diphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson’s disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, diphenhydramine competes with free histamine for binding at HA-receptor sites. Diphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of diphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.

LD50=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.

Imprints


Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: L 6
Color: Blue & Gray
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: 44 235
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: AP 133
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: BP50
Color: Blue & White
Shape: Round

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: AZ 267
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: CPC752
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 325 Mg / 12.5 Mg
Pill Imprint: TCL 106
Color: Peach
Shape: Round

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Drug: Diphenhydramine
Strength: 325 Mg / 12.5 Mg
Pill Imprint: AP 126
Color: Orange
Shape: Round

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: TCL 357
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Acetaminophen 500 Mg / Diphenhydramine Hydrochlori
Pill Imprint: S525
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 38 Mg
Pill Imprint: 44 373
Color: Blue
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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: C 24
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: K 54
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: Acetaminophen 500 Mg / Diphenhydramine Hydrochlori
Pill Imprint: V15AV
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: GP 325
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Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Acetaminophen 500 Mg / Diphenhydramine 25 Mg
Pill Imprint: L355 PM
Color: Blue
Shape: Round

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Drug: Diphenhydramine
Strength: Acetaminophen 500 Mg / Diphenhydramine 25 Mg
Pill Imprint: 44 556
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
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Color: Blue
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Drug: Diphenhydramine
Strength: 325 Mg / 12.5 Mg / 5 Mg
Pill Imprint: AAA 1115
Color: White
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: AZ 020
Color: Blue
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Drug: Diphenhydramine
Strength: 500 Mg / 12.5 Mg
Pill Imprint: 44 518
Color: Yellow
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 500 Mg / 25 Mg
Pill Imprint: BPI 50
Color: Blue & White
Shape: Round

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Drug: Diphenhydramine
Strength: 325 Mg / 25 Mg / 5 Mg
Pill Imprint: AAA 1116
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 650 Mg / 25 Mg / 10 Mg
Pill Imprint: RC CPE
Color: White
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 500 Mg / 12.5 Mg
Pill Imprint: AAA 1094
Color: Yellow
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 325 Mg / 12.5 Mg / 5 Mg
Pill Imprint: AAA 115
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Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: BENADRYL
Color: Pink & White
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Drug: Diphenhydramine
Strength: 50 MG
Pill Imprint: P-D 373
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Drug: Diphenhydramine
Strength: Diphenhydramine 25 Mg
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Drug: Diphenhydramine
Strength: Diphenhydramine 25 Mg
Pill Imprint: Ben A
Color: Pink & White
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Drug: Diphenhydramine
Strength: 12.5 MG
Pill Imprint: BENADRYL 12.5
Color: Purple
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
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Drug: Diphenhydramine
Strength: 25 Mg
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Drug: Diphenhydramine
Strength: 25 Mg
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Color: Pink & White
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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: Barr 059
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Drug: Diphenhydramine
Strength: 50 Mg
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: CPC 835
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Drug: Diphenhydramine
Strength: 50 Mg
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Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: T
Color: Pink
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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: CPC 836
Color: Pink
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: K 115
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: T129
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: MUTUAL 103 MUTUAL 103
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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: AP 023
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Shape: Round

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: K 6
Color: Pink
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: K 40
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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: K6
Color: Blue
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
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Color: Pink / Clear
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44107
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: K 46
Color: Pink & White
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: L406
Color: Blue
Shape: Round

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: K 48
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: 01151111
Color: Pink
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 25 L479
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44 107 44 107
Color: Pink / Red
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44 329
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: L462 L462
Color: Pink & White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: PH014 PH014
Color: Pink & White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 1008 1008
Color: Blue
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg / 10 Mg
Pill Imprint: TCL 124
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: AP 21
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: AP 20
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: RUGBY 3762 RUGBY 3762
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: AZ 247
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: AZ 048
Color: Pink
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 2824
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: SP29
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: L431
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: V 25
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: P50
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44 367
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Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: L151
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Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 048 D
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg / 10 Mg
Pill Imprint: 44 485
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: S4
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 93 XF 57344
Color: White
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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 25 052
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Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: C22
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: A99
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: S 25
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: A33
Color: Yellow
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: A 20
Color: Pink & White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44 190
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: S5
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 93XF 57344
Color: Blue
Shape: Round

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Drug: Diphenhydramine
Strength: 12.5 Mg
Pill Imprint: 44 599
Color: Pink
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: R060
Color: Purple
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 12.5 Mg
Pill Imprint: 44 585
Color: Purple
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44 618
Color: White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: BE
Color: Pink
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: R M
Color: Blue
Shape: Round

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: Ph 011
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: 293
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44 614
Color: White
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44107
Color: Pink & White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Diphenhydramine 25 Mg
Pill Imprint: S
Color: Blue
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: AP 135
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: AP 20
Color: Pink & White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Diphenhydramine 50 Mg
Pill Imprint: PH013 PH013
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Diphenhydramine 50 Mg
Pill Imprint: S
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Diphenhydramine 25 Mg
Pill Imprint: Help Help
Color: White
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: Zzz
Color: Purple
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: Logo 20
Color: Pink & White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 MG
Pill Imprint: HAW 571
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: SL
Color: Blue
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Diphenhydramine Hydrochloride 25 Mg
Pill Imprint: T 061
Color: Pink
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 50 Mg
Pill Imprint: UNISOM
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: Diphenhydramine Hydrochloride 25 Mg
Pill Imprint: 25
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: Diphenhydramine Hydrochloride 25 Mg
Pill Imprint: ALVA
Color: White
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: T061
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: N
Color: White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 44-191
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: U
Color: Pink
Shape: Round

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: NL/753
Color: Blue
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: 042
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: N
Color: White
Shape: Capsule-shape

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Drug: Diphenhydramine
Strength: Diphenhydramine Hydrochloride 25 Mg
Pill Imprint: CRX
Color: Red
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: 25 Mg
Pill Imprint: G17
Color: Pink
Shape: Elliptical / Oval

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Drug: Diphenhydramine
Strength: Diphenhydramine Hydrochloride 25 Mg
Pill Imprint: VNT
Color: Blue
Shape: Elliptical / Oval

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