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Effexor

Effexor (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI ) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that effexor may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Effexor was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006.

Effexor potentiates the neurotransmitter activity in the central nervous system. Furthermore, effexor and its metabolite, O-desmethyleffexor (ODV) potently inhibit the reuptake of serotonin and norepinephrine and weakly inhibit dopamine reuptake. Both molecules do not bind to muscarinic, histaminergic, or alpha-1 adrenergic receptors. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Both also do not have any monoamine oxidase (MAO) inhibitory activity.

Most patients overdosing with effexor develop only mild symptoms. However, severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. Effexor’s toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large doses.

Imprints


Drug: Effexor
Strength: 75 Mg
Pill Imprint: W 75 704
Color: Orange
Shape: Five-sided

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Drug: Effexor
Strength: 50 Mg
Pill Imprint: W 50 703
Color: Orange
Shape: Five-sided

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Drug: Effexor
Strength: 37.5 Mg
Pill Imprint: W 37.5 781
Color: Orange
Shape: Five-sided

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Drug: Effexor
Strength: 100 Mg
Pill Imprint: W 100 705
Color: Orange
Shape: Five-sided

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Drug: Effexor
Strength: 25 Mg
Pill Imprint: W 25 701
Color: Orange
Shape: Five-sided

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