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Fetzima

Fetzima is a selective serotonin and norepinephrine reuptake inhibitor. Chemically, fetzima is the 1S,2R-enantiomer of milnacipran. FDA approved on July 25, 2013.

Fetzima binds with high affinity to human serotonin (5-HT) and norepinephrine (NE) transporters (Ki = 11 and 91 nM, respectively). It potently inhibits 5-HT and NE reuptake (IC50 = 16 – 19 and 11 nM, respectively). Fetzima does not bind to any other receptors, ion channels, or transporters, including serotonergic (5HT1-7), α- and β adrenergic, muscarinic, or histaminergic receptors and Ca2+, Na+, K+ or Cl- channels to a significant degree. Fetzima did not inhibit monoamine oxidase (MAO). Furthermore, fetzima does not prolong the QTc interval to a clinically relevant extent.

The most common adverse reactions are nausea, constipation, hyperhidrosis, heart rate increase, erectile dysfunction, tachycardia, vomiting, and palpitations.

Imprints


Drug: Fetzima
Strength: 40 Mg
Pill Imprint: FL 40
Color: Yellow
Shape: Capsule-shape

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Drug: Fetzima
Strength: 20 Mg
Pill Imprint: FL 20
Color: Yellow & White
Shape: Capsule-shape

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Drug: Fetzima
Strength: 80 Mg
Pill Imprint: FL 80
Color: Pink & White
Shape: Capsule-shape

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Drug: Fetzima
Strength: 120 Mg
Pill Imprint: FL 120
Color: Pink
Shape: Capsule-shape

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