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Fluoxetine

Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Fluoxetine may be used to treat major depressive disorder (MDD ), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD ), premenstrual dysphoric disorder (PMDD ), panic disorder with or without agoraphobia, and in combination with olanzapine for treatment-resistant or bipolar I depression. Fluoxetine is the most anorexic and stimulating SSRI .

Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine’s effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level. Antagonism of muscarinic, histaminergic, and α1–adrenergic receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects of classical tricyclic antidepressant (TCA) drugs. Fluoxetine binds to these and other membrane receptors from brain tissue much less potently in vitro than do the tricyclic drugs.

Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD50=284mg/kg (orally in mice). The most frequent side effects include: nervous system effects such as anxiety, nervousness, insomnia, drowsiness, fatigue or asthenia, tremor, and dizziness or lightheadedness; GI effects such as anorexia, nausea, and diarrhea; vasodilation; dry mouth; abnormal vision; decreased libido; abnormal ejaculation; rash; and sweating. Withdrawal symptoms include flu-like symptoms, insomnia, nausea, imbalance, sensory changes and hyperactivity.

Imprints


Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: GG 550 GG 550
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: Logo 4356 20 Mg
Color: Blue
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: PLIVA 647 PLIVA 647
Color: White / Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: E 91
Color: Green & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: G FL 20
Color: White
Shape: Elliptical / Oval

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: G FL 10
Color: White
Shape: Elliptical / Oval

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: 20 A106
Color: Blue
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: 93 7198 93 7198
Color: Blue & Orange
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: Barr 20 Mg 877
Color: Blue & Gray
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: GG 540 GG 540
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: 93 42 93 42
Color: Blue
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: E 88
Color: Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: 9 3 7188
Color: Blue
Shape: Elliptical / Oval

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: 872 Par
Color: Blue & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: 10 A105
Color: Blue & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: RX632 RX632
Color: Green / Orange
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: 40 A107
Color: Blue
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: M 0663
Color: Green & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: GG 575 GG 575
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: 93 43 93 43
Color: Blue & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: FLUOXETINE 40mg R149
Color: Blue / White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: E 92
Color: Green & Orange
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: Logo 4363 10 Mg
Color: Turquoise & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: Logo 4346 40 Mg
Color: Blue
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: G FL 20
Color: Purple / Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: M 0661
Color: Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: E85 E85
Color: Green & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: Barr 10 Mg 876
Color: Blue & Yellow
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: MYLAN 4220 MYLAN 4220
Color: Blue & Pink
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: G FL 10
Color: Purple / Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: B 201 10
Color: Beige
Shape: Elliptical / Oval

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: MYLAN 4210 MYLAN 4210
Color: Pink & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: MYLAN 5410 MYLAN 5410
Color: Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: MYLAN 5420 MYLAN 5420
Color: Red
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: Logo 4510
Color: Green
Shape: Elliptical / Oval

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: S 662
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: S 661
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: PLIVA 648
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: FLUOXETINE 20mg R148
Color: Blue / Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: TEVA 7198
Color: Blue & Orange
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: FLUOXETINE 10mg R147
Color: Blue
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: MYLAN 4350 MYLAN 4350
Color: Blue & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 60 Mg
Pill Imprint: FL 60
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 50 Mg / 6 Mg
Pill Imprint: Par 251
Color: Yellow & Gray
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 90 Mg
Pill Imprint: Barr 90 Mg 871
Color: Green & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 50 Mg / 12 Mg
Pill Imprint: Par 253
Color: Gray & Red
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 50 Mg / 12 Mg
Pill Imprint: TEVA 5507
Color: Maroon
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 25 Mg / 6 Mg
Pill Imprint: TEVA 5504
Color: Orange
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 90 Mg
Pill Imprint: RDY 284
Color: Brown & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 25 Mg / 12 Mg
Pill Imprint: TEVA 5506
Color: Yellow
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 25 Mg / 3 Mg
Pill Imprint: Par 277
Color: Yellow & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 50 Mg / 6 Mg
Pill Imprint: TEVA 5505
Color: White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 25 Mg / 6 Mg
Pill Imprint: 250 Par
Color: Yellow
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 25 Mg / 3 Mg
Pill Imprint: TEVA 5503
Color: Beige
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 25 Mg / 12 Mg
Pill Imprint: Par 252
Color: Red / Tan
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: RX687 RX687
Color: Green & Yellow
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: RX686 RX686
Color: Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: HP29
Color: Green & Yellow
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: HP 30
Color: Green & Orange
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: HP28
Color: Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: SG 113
Color: Blue & Orange
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: SG 114
Color: Blue / Green
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 40 Mg
Pill Imprint: SG 115
Color: Blue & White
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: Lilly 3210 10 Mg
Color: Purple
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: Lilly 3220 20 Mg
Color: Pink / Purple
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: 93 7226 93 7226
Color: Blue & Pink
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: 93 7225 93 7225
Color: Blue
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: S10
Color: Beige
Shape: Round

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: S20
Color: Yellow
Shape: Round

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Drug: Fluoxetine
Strength: 20 Mg
Pill Imprint: Sarafem 20 Mg
Color: Pink & Purple
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 10 Mg
Pill Imprint: Sarafem 10 Mg
Color: Purple
Shape: Capsule-shape

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Drug: Fluoxetine
Strength: 15 Mg
Pill Imprint: S15
Color: White
Shape: Round

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