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Glucotrol

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.

Glucotrol, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II. The primary mode of action of glucotrol in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet tissue and is thus dependent on functioning beta cells in the pancreatic islets. In humans glucotrol appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. In man, stimulation of insulin secretion by glucotrol in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term glucotrol administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment. Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including glucotrol.

The acute oral toxicity was extremely low in all species tested (LD50 greater than 4 g/kg). Overdosage of sulfonylureas including glucotrol can produce hypoglycemia.

Imprints


Drug: Glucotrol
Strength: 5 Mg
Pill Imprint: PFIZER 411
Color: White
Shape: Four-sided

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Drug: Glucotrol
Strength: 10 Mg
Pill Imprint: GLUCOTROL XL 10
Color: White
Shape: Round

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Drug: Glucotrol
Strength: 10 Mg
Pill Imprint: GXL 10
Color: White
Shape: Round

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Drug: Glucotrol
Strength: 5 Mg
Pill Imprint: GLUCOTROL XL 5
Color: White
Shape: Round

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Drug: Glucotrol
Strength: 10 Mg
Pill Imprint: PFIZER 412
Color: White
Shape: Four-sided

View Images & Details

Drug: Glucotrol
Strength: 5 Mg
Pill Imprint: GXL 5
Color: White
Shape: Round

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Drug: Glucotrol
Strength: 2.5 Mg
Pill Imprint: GLUCOTROL XL 2.5
Color: Blue
Shape: Round

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Drug: Glucotrol
Strength: 2.5 Mg
Pill Imprint: GXL 2.5
Color: Blue
Shape: Round

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Drug: Glucotrol
Strength: 5 Mg
Pill Imprint: PFIZER 411
Color: White
Shape: Four-sided

View Images & Details

Drug: Glucotrol
Strength: 10 Mg
Pill Imprint: PFIZER 412
Color: White
Shape: Four-sided

View Images & Details
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