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Glyburide

Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM ). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide’s hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions. The half-life of glyburide appears to be unaffected in those with a creatinine clearance of greater than 29 ml/min/1.73m2.

Glyburide, a second-generation sulfonylurea antidiabetic agent, lowers blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonyl-urea hypoglycemic drugs. The combination of glibenclamide and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different but complementary mechanisms. In addition to its blood glucose lowering actions, glyburide produces a mild diuresis by enhancement of renal free water clearance. Glyburide is twice as potent as the related second-generation agent glipizide.

Oral rat LD50: > 20,000 mg/kg. Oral mouse LD50: 3250 mg/kg.

Imprints


Drug: Glyburide
Strength: 5 Mg
Pill Imprint: N 344 5
Color: Green
Shape: Round

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: GLYBUR
Color: Blue
Shape: Capsule-shape

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: Cor 125
Color: Green
Shape: Round

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: 364 364 GLYBUR
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: N 343 2.5
Color: Orange
Shape: Round

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: A 3 1
Color: White
Shape: Round

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: I37
Color: Blue
Shape: Capsule-shape

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: Cor 124
Color: Yellow
Shape: Round

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: GLYBUR
Color: Pink
Shape: Capsule-shape

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: GLYBUR 433 433
Color: Pink
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: Cor 123
Color: White
Shape: Round

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: GG 238
Color: White
Shape: Round

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: G 3727
Color: Blue
Shape: Round

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: A 3 0
Color: White
Shape: Round

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: GLYBUR
Color: White
Shape: Capsule-shape

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: N 342 1.25
Color: White
Shape: Round

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: 477 477 GLYBUR
Color: White
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: GG 240
Color: Blue
Shape: Round

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: I36
Color: Pink
Shape: Capsule-shape

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Drug: Glyburide
Strength: 6 Mg
Pill Imprint: H 5
Color: Yellow
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 3 Mg
Pill Imprint: G 2
Color: Blue
Shape: Capsule-shape

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Drug: Glyburide
Strength: 2.5 MG
Pill Imprint: GG 239
Color: Pink
Shape: Round

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: A 2 9
Color: White
Shape: Round

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: I35
Color: White
Shape: Capsule-shape

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: G 3726
Color: Pink
Shape: Round

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: G 3725
Color: White
Shape: Round

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Drug: Glyburide
Strength: 6 MG
Pill Imprint: G3783
Color: Yellow
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.5 Mg
Pill Imprint: G 1
Color: White
Shape: Capsule-shape

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Drug: Glyburide
Strength: 6 Mg
Pill Imprint: N 6 036
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 3 Mg
Pill Imprint: 3 035 N
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 3 Mg
Pill Imprint: M 125
Color: Yellow
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: Micronized 3 Mg
Pill Imprint: COPLEY 381 381
Color: Green
Shape: Six-sided

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Drug: Glyburide
Strength: 1.5 MG
Pill Imprint: 725 725 COPLEY
Color: Pink
Shape: Six-sided

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Drug: Glyburide
Strength: 6 Mg
Pill Imprint: M 142
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: Micronized 1.5 Mg
Pill Imprint: MOVA MO3 1.5
Color: White
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.5 Mg
Pill Imprint: M 113
Color: White
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: Micronized 3 Mg
Pill Imprint: MOVA MO4 3.0
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 3 Mg
Pill Imprint: MOVA M04 3.0
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.5 MG
Pill Imprint: G 3781
Color: White
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.5 Mg
Pill Imprint: 1.5 034 N
Color: White
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 3 MG
Pill Imprint: G 3782
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.5 Mg
Pill Imprint: MOVA M03 1.5
Color: White
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 6 Mg
Pill Imprint: MOVA M07 6.5
Color: Yellow
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: Micronized 6 Mg
Pill Imprint: A135
Color: Yellow
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 3 Mg
Pill Imprint: A134
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: MICRONASE 5
Color: Green
Shape: Round

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: Dia B HOECHST
Color: Green
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.5 MG
Pill Imprint: GLYNASE 1.5 PT PT
Color: White
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 1.25 MG
Pill Imprint: MICRONASE 1.25
Color: White
Shape: Round

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: Dia B HOECHST
Color: Pink
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 2.5 MG
Pill Imprint: MICRONASE 2.5
Color: Pink
Shape: Round

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: Dia B HOECHST
Color: Peach
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 3 Mg
Pill Imprint: PT PT GLYNASE 3
Color: Blue
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 6 Mg
Pill Imprint: PT PT GLYNASE 6
Color: Yellow
Shape: Elliptical / Oval

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Drug: Glyburide
Strength: 2.5 Mg
Pill Imprint: Dia B
Color: Pink
Shape: Capsule-shape

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Drug: Glyburide
Strength: 5 Mg
Pill Imprint: Dia B
Color: Green
Shape: Capsule-shape

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Drug: Glyburide
Strength: 1.25 Mg
Pill Imprint: Dia B
Color: Peach
Shape: Elliptical / Oval

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