866-897-8297

Call Is Confidential & Toll Free

Ibrance

Ibrance is an oral, reversible, selective, small-molecule inhibitor of CDK4 and CDK6 indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. CDK4 and CDK6 along with their regulatory partner cyclin D1 play a key role in regulating the G1- to S-phase cell-cycle transition via regulation of phosphorylation of the retinoblastoma (Rb) protein. Inhibition of these proteins leads to reduced phosphorylation of Rb, inhibition of downstream signalling, and increased tumor growth arrest. Ibrance received an accelerated approval from the Food and Drug Administration on February 3, 2015.

Treatment of breast cancer cell lines with the combination of ibrance and antiestrogens leads to decreased retinoblastoma protein (Rb) phosphorylation resulting in reduced E2F expression and signaling and increased growth arrest compared to treatment with each drug alone. In vitro treatment of ER-positive breast cancer cell lines with the combination of ibrance and antiestrogens leads to increased cell senescence, which was sustained for up to 6 days following drug removal. In vivo studies using a patient-derived ER-positive breast cancer xenograft model demonstrated that the combination of ibrance and letrozole increased the inhibition of Rb phosphorylation, downstream signaling and tumor growth compared to each drug alone.

Imprints


Drug: Ibrance
Strength: 75 Mg
Pill Imprint: Pfizer PBC 75
Color: Orange
Shape: Capsule-shape

View Images & Details

Drug: Ibrance
Strength: 100 Mg
Pill Imprint: Pfizer PBC 100
Color: Tan / Orange
Shape: Capsule-shape

View Images & Details

Drug: Ibrance
Strength: 125 Mg
Pill Imprint: Pfizer PBC 125
Color: Tan
Shape: Capsule-shape

View Images & Details
Disclaimer: We strive to ensure that the content on pilladdictions.com is current and factual at the time it was written. However, because new information and discoveries are always becoming available, we are not making any representations or warranties with respect to this content. Please always rely on the guidance of your physician for information about the drugs you are taking and the impacts they may or may not have on your health.

Questions About Prescription Drug Addiction?

(888) 740-2069

Questions About Prescription Drug Addiction?