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Imodium

One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.

Imodium is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Imodium is also indicated for reducing the volume of discharge from ileostomies. In man, Imodium prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Imodium is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Imodium also decreases colonic mass movements and suppresses the gastrocolic reflex.

Oral, mouse: LD50 = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.

Imprints


Drug: Imodium
Strength: 2 Mg
Pill Imprint: IMODIUM JANSSEN
Color: Green / Green
Shape: Capsule-shape

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Drug: Imodium
Strength: 2 Mg / 125 Mg
Pill Imprint: IMO 2 125
Color: White
Shape: Elliptical / Oval

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Drug: Imodium
Strength: 2 Mg / 125 Mg
Pill Imprint: IMODIUM 2 125
Color: Green
Shape: Round

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Drug: Imodium
Strength: 2 Mg
Pill Imprint: IMODIUM AD 2 MG
Color: Green
Shape: Elliptical / Oval

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Drug: Imodium
Strength: 2 Mg
Pill Imprint: IMO 2 MG
Color: Green
Shape: Round

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