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Invokamet

Invokamet belongs to a new class of anti-diabetic drugs that works by inhibiting the sodium-glucose transport protein (SGLT2). This transport protein is found in the kidney and is responsible for reabsorbing glucose that has been filtered. FDA approved on March 29, 2013.

Invokamet binds to SGLT2 more potently (250-times) than SGLT1 in vitro. The 50% inhibitory concentrations (IC50) are 2.2-4.4 nmol/L and 684 – 910 nmol/L for SGLT2 and SGLT1 respectively. Dose dependent decreases in renal threshold for glucose and increases in urinary glucose excretion were observed when single and multiple oral doses were administered to type 2 diabetes patients. Decreases in plasma glucose in a dose-dependent fashion were also noted as early as the first day of administration. When given to healthy and type 2 diabetic patients before a meal, a delay in intestinal glucose absorption and a reduction in postprandial glucose was observed. Invokamet does not prolong the QTc interval.

Most common adverse reactions associated with invokamet (5% or greater incidence): female genital mycotic infections, urinary tract infection, and increased urination.

Imprints


Drug: Invokamet
Strength: 50 Mg / 500 Mg
Pill Imprint: CM 155
Color: White
Shape: Capsule-shape

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Drug: Invokamet
Strength: 50 Mg / 1000 Mg
Pill Imprint: CM 551
Color: Beige
Shape: Capsule-shape

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Drug: Invokamet
Strength: 150 Mg / 500 Mg
Pill Imprint: CM 215
Color: Yellow
Shape: Capsule-shape

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Drug: Invokamet
Strength: 150 Mg / 1000 Mg
Pill Imprint: CM 611
Color: Purple
Shape: Capsule-shape

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