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Kadian

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Kadian has widespread effects in the central nervous system and on smooth muscle.

Kadian is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Kadian interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, kadian exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Kadian appears to increase the patient’s tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.

LD50 = 461 mg/kg (rat, oral), 600 mg/kg (mouse, oral). Human lethal dose by ingestion is 120-250 mg of kadian sulfate. Symptoms of overdose include cold, clammy skin, flaccid muscles, fluid in the lungs, lowered blood pressure, “pinpoint” or dilated pupils, sleepiness leading to stupor and coma, slowed breathing, and slow pulse rate.

Imprints


Drug: Kadian
Strength: 30 Mg
Pill Imprint: KADIAN 30 Mg
Color: Purple
Shape: Capsule-shape

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Drug: Kadian
Strength: 20 Mg
Pill Imprint: KADIAN 20 Mg
Color: Yellow
Shape: Capsule-shape

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Drug: Kadian
Strength: 50 Mg
Pill Imprint: KADIAN 50 Mg
Color: Blue
Shape: Capsule-shape

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Drug: Kadian
Strength: 100 Mg
Pill Imprint: KADIAN 100 Mg
Color: Green
Shape: Capsule-shape

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Drug: Kadian
Strength: 60 Mg
Pill Imprint: KADIAN 60 Mg
Color: Pink
Shape: Capsule-shape

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Drug: Kadian
Strength: 80 Mg
Pill Imprint: KADIAN 80 Mg
Color: Orange
Shape: Capsule-shape

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Drug: Kadian
Strength: 10 Mg
Pill Imprint: KADIAN 10 Mg
Color: Blue
Shape: Capsule-shape

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Drug: Kadian
Strength: 200 Mg
Pill Imprint: KADIAN 200 Mg
Color: Brown
Shape: Capsule-shape

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Drug: Kadian
Strength: 40 Mg
Pill Imprint: KADIAN 40 Mg
Color: Blue & Yellow
Shape: Capsule-shape

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Drug: Kadian
Strength: 130 Mg
Pill Imprint: KADIAN 130 Mg
Color: Brown & Orange
Shape: Capsule-shape

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Drug: Kadian
Strength: 150 Mg
Pill Imprint: KADIAN 150 Mg
Color: Green / Brown
Shape: Capsule-shape

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Drug: Kadian
Strength: 70 Mg
Pill Imprint: KADIAN 70 Mg
Color: Blue
Shape: Capsule-shape

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