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Losartan

Losartan is an angiotensin-receptor blocker (ARB ) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS ); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE ) inhibitors, ARBs do not have the adverse effect of dry cough. Losartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.

Losartan is the first of a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Losartan and its longer acting active metabolite, E-3174, are specific and selective type-1 angiotensin II receptor (AT1) antagonists which block the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system (RAAS). RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering cardiovascular structure. Angiotensin II binds to two receptors: AT1 and type-2 angiotensin II receptor (AT2). AT1 is a G-protein coupled receptor (GPCR) that mediates the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Studies performed in recent years suggest that AT2 antagonizes AT1-mediated effects and directly affects long-term blood pressure control by inducing vasorelaxation and increasing urinary sodium excretion. Angiotensin receptor blockers (ARBs) are non-peptide competitive inhibitors of AT1. ARBs block the ability of angiotensin II to stimulate pressor and cell proliferative effects. Unlike ACE inhibitors, ARBs do not affect bradykinin-induced vasodilation. The overall effect of ARBs is a decrease in blood pressure.

Hypotension and tachycardia; Bradycardia could occur from parasympathetic (vagal) stimulation, LD50= 1000 mg/kg (orally in rat)

Imprints


Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: SZ 390
Color: White
Shape: Round

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: 93 7367
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: SZ 349
Color: White
Shape: Round

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: 93 7368
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: 93 7369
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: E 49
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: 116
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: 1118
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: SZ 309
Color: White
Shape: Round

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: E 48
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: LU M43
Color: Yellow
Shape: Egg-shape

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: 1117
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: LU M41
Color: Yellow
Shape: Capsule-shape

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: F 74
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: APO 100 25
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: ZD19
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: 54 931
Color: White
Shape: Round

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: LU M42
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: 54 557
Color: Yellow
Shape: Round

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: APO 100 12.5
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: APO 50 12.5
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: ZD18
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: 54 717
Color: Yellow
Shape: Round

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: 717
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: 745
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: 747
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: C 337
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: C 339
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: C 338
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: L146
Color: Yellow
Shape: Egg-shape

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: L145
Color: Yellow
Shape: Egg-shape

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: L144
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: > LH2
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: > LH3
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: M LH4
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: M LH5
Color: Orange
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: M LH6
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: > LH1
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 50 Mg
Pill Imprint: ML 43
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg / 100 Mg
Pill Imprint: ML 44
Color: Yellow
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 12.5 Mg / 100 Mg
Pill Imprint: ML 42
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: 93 7365
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: 114
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: Logo 573
Color: White
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: 93 7366
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: 93 7364
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: SZ 213
Color: Pink
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: SZ 214
Color: Pink
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: Z18
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: Logo 574
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: APO LS 50
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: Z16
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: HH 112
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: LU P22
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: 100 115
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: HH 113
Color: White
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: LU P23
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: E 47
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: Logo 572
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: E 46
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: 54 125
Color: Green
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: APO LS100
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: SZ 210
Color: Pink
Shape: Round

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: APO LS 25
Color: White
Shape: Round

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: Z 2
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: L126
Color: Green
Shape: Round

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: 25 113
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: 54 357
Color: Green
Shape: Round

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: LU P21
Color: White
Shape: Capsule-shape

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: LK100 >
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: LK 50 >
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: HH 111
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: L142
Color: Green
Shape: Round

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: E 45
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: LK 25 >
Color: Green
Shape: Egg-shape

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: L143
Color: Green
Shape: Round

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: 54 277
Color: Green
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: US 94
Color: Green
Shape: Round

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: US 93
Color: Green
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: US 95
Color: Green
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: M LN50
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: M LN100
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: M LN25
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: C 335
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: 960
Color: White
Shape: Egg-shape

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: A50
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: A 25
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: C 333
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: A100
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: 952
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: 951
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: S 111
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: S 11 2
Color: White
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: S 113
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: Logo 5 73
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: CL14
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: C 334
Color: Green
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: CL11
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: CL17
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: 11
Color: White
Shape: Round

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: 12
Color: White
Shape: Round

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: 13
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: I 5
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: I 6
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: H 145
Color: White
Shape: Egg-shape

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: 952
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: MRK 960
Color: Green
Shape: Egg-shape

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Drug: Losartan
Strength: 100 Mg
Pill Imprint: 960
Color: White
Shape: Egg-shape

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Drug: Losartan
Strength: 50 Mg
Pill Imprint: MRK 952 COZAAR
Color: Green
Shape: Egg-shape

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: 951
Color: White
Shape: Elliptical / Oval

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Drug: Losartan
Strength: 25 Mg
Pill Imprint: MRK 951
Color: Green
Shape: Egg-shape

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