A bacteriostatic or bactericidal agent depending on the concentration and susceptibility of the infecting organism. Macrobid is active against some gram positive organisms such as S. aureus, S. epidermidis, S. saprophyticus, Enterococcus faecalis, S. agalactiae, group D streptococci, viridians streptococci and Corynebacterium. Its spectrum of activity against gram negative organisms includes E. coli, Enterobacter, Neisseria, Salmonella and Shigella. It may be used as an alternative to trimethoprim/sulfamethoxazole for treating urinary tract infections though it may be less effective at eradicating vaginal bacteria. May also be used in females as prophylaxis against recurrent cystitis related to coitus. Macrobid is highly stable to the development of bacterial resistance, a property thought to be due to its multiplicity of mechanisms of action.
Macrobid exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein and cell wall synthesis.
Acute toxicity may cause vomiting. Adverse effects include nausea and urine discolouration. Rare hepatotoxic and hypersensitivity reactions have occurred. Hemolytic anemia is a risk in patients with G6PD deficiency. Ascending polyneuropathy may occur with prolonged therapy or in patients with low creatinine clearance.
Imprints
Drug: Macrobid
Strength: 100 Mg
Pill Imprint: Macrobid Norwich Eaton
Color: Black & Yellow
Shape: Capsule-shape
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Drug: Macrobid
Strength: 100 Mg
Pill Imprint: Macrobid 285
Color: Black & Yellow
Shape: Capsule-shape
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