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Methotrexate

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA .

Methotrexate is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine – which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the “S” phase (of the cell cycle), stopping normal development and division. Methotrexate inhibits folic acid reductase which is responsible for the conversion of folic acid to tetrahydrofolic acid. At two stages in the biosynthesis of purines and at one stage in the synthesis of pyrimidines, one-carbon transfer reactions occur which require specific coenzymes synthesized in the cell from tetrahydrofolic acid. Tetrahydrofolic acid itself is synthesized in the cell from folic acid with the help of an enzyme, folic acid reductase. Methotrexate looks a lot like folic acid to the enzyme, so it binds to it quite strongly and inhibits the enzyme. Thus, DNA synthesis cannot proceed because the coenzymes needed for one-carbon transfer reactions are not produced from tetrahydrofolic acid because there is no tetrahydrofolic acid. Methotrexate selectively affects the most rapidly dividing cells (neoplastic and psoriatic cells). Methotrexate is also indicated in the management of severe, active, classical, or definite rheumatoid arthritis.

Symptoms of overdose include bone marrow suppression and gastrointestinal toxicity. LD50=43mg/kg(orally in rat).

Imprints


Drug: Methotrexate
Strength: 2.5 Mg
Pill Imprint: M 14
Color: Orange
Shape: Round

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Drug: Methotrexate
Strength: 2.5 Mg
Pill Imprint: B 572
Color: Yellow
Shape: Elliptical / Oval

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Drug: Methotrexate
Strength: 2.5 Mg
Pill Imprint: M 1
Color: Yellow
Shape: Round

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Drug: Methotrexate
Strength: 2.5 Mg
Pill Imprint: 54 323
Color: Yellow
Shape: Round

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Drug: Methotrexate
Strength: 2.5 MG
Pill Imprint: LL M 1
Color: Yellow
Shape: Round

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Drug: Methotrexate
Strength: 2.5 MG
Pill Imprint: 511 M X
Color: Yellow
Shape: Round

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Drug: Methotrexate
Strength: 2.5 Mg
Pill Imprint: 572 Logo
Color:
Shape:

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Drug: Methotrexate
Strength: 7.5 Mg
Pill Imprint: B 928 7 1/2
Color: Blue
Shape: Elliptical / Oval

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Drug: Methotrexate
Strength: 5 Mg
Pill Imprint: B 927 5
Color: Green
Shape: Elliptical / Oval

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Drug: Methotrexate
Strength: 15 Mg
Pill Imprint: B 945 15
Color: Purple
Shape: Elliptical / Oval

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Drug: Methotrexate
Strength: 10 Mg
Pill Imprint: B 929 10
Color: Pink
Shape: Elliptical / Oval

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