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Namenda

Namenda is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is a noncompetitive NMDA receptor antagonist that binds preferentially to NMDA receptor-operated cation channels. It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. It is under investigation for the treatment of Alzheimer’s disease, but there has been no clinical support for the prevention or slowing of disease progression.

Namenda, an amantadine derivative, is an NMDA receptor antagonist used in the treatment of Alzheimer’s disease. It differs from traditional agents used in Alzheimer’s disease by acting on glutamatergic neurotransmission, rather than cholinergic. There is some evidence that dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is involved in the aetiology of Alzheimer’s disease (Cacabelos et al., 1999). As such, targeting the glutamatergic system, specifically NMDA receptors, was a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system. A systematic review of randomised controlled trials found that namenda has a positive effect on cognition, mood, behaviour, and the ability to perform daily activities. There is no evidence that namenda prevents or slows neurodegeneration in patients with Alzheimer’s disease.

Side effects include pain, abnormal crying, leg pain, fever, increased apetite. Adverse drug reactions include: dizziness, confusion, headache, hallucinations, tiredness. Less common side effects include: vomiting, anxiety, hypertonia, cystitis, and increased libido. Doses of up to 400 mg have been tolerated.

Imprints


Drug: Namenda
Strength: 10 Mg
Pill Imprint: 10 FL
Color: Gray
Shape: Capsule-shape

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Drug: Namenda
Strength: 5 Mg
Pill Imprint: 5 FL
Color: Tan
Shape: Capsule-shape

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Drug: Namenda
Strength: 28 Mg
Pill Imprint: FLI 28 Mg
Color: Green
Shape: Capsule-shape

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Drug: Namenda
Strength: 14 Mg
Pill Imprint: FLI 14 Mg
Color: Yellow / Green
Shape: Capsule-shape

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Drug: Namenda
Strength: 7 Mg
Pill Imprint: FLI 7 Mg
Color: Yellow
Shape: Capsule-shape

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Drug: Namenda
Strength: 21 Mg
Pill Imprint: FLI 21 Mg
Color: White / Green
Shape: Capsule-shape

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