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Norvasc

Norvasc is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, norvasc prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that norvasc also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Norvasc is used to treat hypertension and chronic stable angina.

Norvasc belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. There are at least five different types of calcium channels in Homo sapiens: L-, N-, P/Q-, R- and T-type. It was widely accepted that DHP CCBs target L-type calcium channels, the major channel in muscle cells that mediate contraction; however, some studies have indicated that norvasc also binds to and inhibits N-type calcium channels (see references in Targets section). Similar to other DHP CCBs, norvasc binds directly to inactive L-type calcium channels stabilizing their inactive conformation. Since arterial smooth muscle depolarizations are longer in duration than cardiac muscle depolarizations, inactive channels are more prevalent in smooth muscle cells. Alternative splicing of the alpha-1 subunit of the channel gives norvasc additional arterial selectivity. At therapeutic sub-toxic concentrations, norvasc has little effect on cardiac myocytes and conduction cells.

Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.

Imprints


Drug: Norvasc
Strength: 5 Mg
Pill Imprint: NORVASC 5
Color: White
Shape: Eight-sided

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Drug: Norvasc
Strength: 10 Mg
Pill Imprint: NORVASC 10
Color: White
Shape: Round

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Drug: Norvasc
Strength: 2.5 Mg
Pill Imprint: NORVASC 2.5
Color: White
Shape: Four-sided

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Drug: Norvasc
Strength: 5 Mg
Pill Imprint: NORVASC 5
Color: White
Shape: Eight-sided

View Images & Details

Drug: Norvasc
Strength: 10 Mg
Pill Imprint: NORVASC 10
Color: White
Shape: Round

View Images & Details

Drug: Norvasc
Strength: 2.5 Mg
Pill Imprint: NORVASC 2.5
Color: White
Shape: Four-sided

View Images & Details
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