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Osphena is a new selective non-hormonal estrogen receptor modulator (SERM ) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.

The half maximal inhibitory concentration (IC50) for estrogen receptor (ER) alpha and beta are 0.8 μM and 1.7 μM, respectively. Osphena has potential uses in the management of osteoporosis in postmenopausal women. It interacts with osteoblasts and osteoclasts in such a way that it reduces bone turnover. It also has potential uses in the prevention of breast cancer. Studies suggest that osphena, in a dose-dependent manner, reduces the incidence of tumours.

Adverse reactions (≥1 percent) include: hot flush, vaginal discharge, muscle spasms, genital discharge, hyperhidrosis.


Drug: Osphena
Strength: 60 Mg
Pill Imprint: 60
Color: White
Shape: Elliptical / Oval

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