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Phenytoin

An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.

Phenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures. Phenytoin acts to dampen the unwanted, runaway brain activity seen in seizure by reducing electrical conductance among brain cells. It lacks the sedation effects associated with phenobarbital. There are some indications that phenytoin has other effects, including anxiety control and mood stabilization, although it has never been approved for those purposes by the FDA. Phenytoin is primarily metabolized by CYP2C9.

Oral, mouse: LD50 = 150 mg/kg; Oral, rat: LD50 = 1635 mg/kg. Symptoms of overdose include coma, difficulty in pronouncing words correctly, involuntary eye movement, lack of muscle coordination, low blood pressure, nausea, sluggishness, slurred speech, tremors, and vomiting.

Imprints


Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: PD DILANTIN 100 Mg
Color: Orange & White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 30 Mg
Pill Imprint: PD DILANTIN 30 Mg
Color: Pink & White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 50 Mg
Pill Imprint: P-D 007
Color: Yellow
Shape: Three-sided

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: DILANTIN 100 Mg
Color: Orange & White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: P-D 362 P-D 362
Color: Orange & White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 30 Mg
Pill Imprint: P-D 365 P-D 365
Color: Pink & White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: Phenobarbital 32 Mg / Phenytoin Sodium 100 Mg
Pill Imprint: P-D 531
Color: White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: MYLAN 1560 MYLAN 1560
Color: Purple / White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: IP 212 IP 212
Color: White / Purple
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: TARO PHN 100 TARO PHN 100
Color: Orange
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: 402 402
Color: White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: BERTEK 560 BERTEK 560
Color: Lavender & White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: W720
Color: Orange
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: Z 2057 Z 2057
Color: White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 50 Mg
Pill Imprint: M P50
Color: Pink
Shape: Round

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Drug: Phenytoin
Strength: 300 Mg
Pill Imprint: 432 432
Color: Blue
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 200 Mg
Pill Imprint: 299 299
Color: Blue / Blue
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 50 Mg
Pill Imprint: PD 007
Color: Yellow
Shape: Three-sided

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Drug: Phenytoin
Strength: 50 Mg
Pill Imprint: T 50
Color: Yellow
Shape: Round

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Drug: Phenytoin
Strength: 50 Mg
Pill Imprint: Cor 212
Color: Peach
Shape: Round

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: UPSHER-SMITH 100 Mg
Color: Orange
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 100 Mg
Pill Imprint: X 51
Color: White
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 300 Mg
Pill Imprint: BERTEK 750 BERTEK 750
Color: Blue
Shape: Capsule-shape

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Drug: Phenytoin
Strength: 200 Mg
Pill Imprint: BERTEK 670 BERTEK 670
Color: Blue
Shape: Capsule-shape

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