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Pravastatin

Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. It was derived from microbial transformation of mevastatin, the first statin discovered. It is a ring-opened dihydroxyacid with a 6’-hydroxyl group that does not require in vivo activation. Pravastatin is one of the lower potency statins; however, its increased hydrophilicity is thought to confer advantages such as minimal penetration through lipophilic membranes of peripheral cells, increased selectivity for hepatic tissues, and a reduction in side effects compared with lovastatin and simvastatin.

The primary cause of cardiovascular (CV) disease is atherosclerotic plaque formation and sustained elevation of cholesterol in the blood increases the risk of CV disease. Pravastatin lowers hepatic production of cholesterol by competitively inhibiting HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in the cholesterol biosynthesis pathway via the mevalonic acid pathway. Decreased hepatic cholesterol levels causes increased uptake of low density lipoprotein (LDL) cholesterol and reduces cholesterol levels in the circulation. Pravastatin also inhibits hepatic synthesis if VLDL. At therapeutic doses, pravastatin lowers LDL cholesterol by 20-30%, increase high density lipoprotein (HDL) cholesterol by 3-10%, and decrease plasma triglycerides by 19-34%. HDL cholesterol is thought to confer protective effects against CV disease, whereas high LDL and triglyceride levels are associated with higher risk of disease.

Side effects include diarrhea, nausea, constipation, gas abdominal pain, myopathy, myositis, rhabdomyolysis, and hepatotoxicity. LD50= 12,000 mg/kg (orally in rat)

Imprints


Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: TEVA 7202
Color: Green
Shape: Round

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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: TEVA 7201
Color: Yellow
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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: 93 7202
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Shape: Round

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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: G5 40
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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: LU N03
Color: Yellow
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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: 93 7201
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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: ZC44
Color: White
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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: RDY 230
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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: LU N02
Color: Yellow
Shape: Capsule-shape

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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: G5 20
Color: Yellow
Shape: Rectangle

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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: RDY 231
Color: White
Shape: Round

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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: APO PRA 40
Color: Green
Shape: Round

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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: ZC45
Color: White
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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: PV 40 >
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Strength: 80 Mg
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Drug: Pravastatin
Strength: 10 Mg
Pill Imprint: TEVA 771
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Drug: Pravastatin
Strength: 10 Mg
Pill Imprint: 93 771
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Drug: Pravastatin
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Drug: Pravastatin
Strength: 80 Mg
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Drug: Pravastatin
Strength: 10 Mg
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Strength: 80 Mg
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Drug: Pravastatin
Strength: 10 Mg
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Strength: 80 Mg
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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: PV 20 >
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Drug: Pravastatin
Strength: 10 Mg
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Strength: 20 Mg
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Drug: Pravastatin
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Pill Imprint: PV 10 >
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Strength: 40 Mg
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Drug: Pravastatin
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Strength: 20 Mg
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Drug: Pravastatin
Strength: 10 Mg
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Strength: 40 Mg
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Color: Brown
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Strength: 80 Mg
Pill Imprint: HLP 80
Color: Brown
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Drug: Pravastatin
Strength: 40 Mg
Pill Imprint: PRAVACHOL 40 LOGO P
Color: Green
Shape: Four-sided

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Strength: 20 MG
Pill Imprint: P PRAVACHOL 20
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Drug: Pravastatin
Strength: 10 Mg
Pill Imprint: PRAVACHOL 10 LOGO P
Color: Pink
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Drug: Pravastatin
Strength: 20 Mg
Pill Imprint: PRAVACHOL 20 LOGO P
Color: Yellow
Shape: Four-sided

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Drug: Pravastatin
Strength: 80 Mg
Pill Imprint: BMS 80
Color: Yellow
Shape: Elliptical / Oval

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