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Saphris

Developed by Schering-Plough after its merger with Organon International, saphris is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Saphris also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.

Saphris is a serotonin, dopamine, noradrenaline, and histamine antagonist in which saphris possess more potent activity with serotonin receptors than dopamine. Sedation in patients is associated with saphris’s antagonist activity at histamine receptors. Its lower incidence of extrapyramidal effects are associated with the upregulation of D1 receptors. This upregulation occurs due to saphris’s dose-dependent effects on glutamate transmission in the brain. It does not have any significant activity with muscarinic, cholinergic receptors therefore symptoms associated with anticholinergic drug activity like dry mouth or constipation are not expected to be observed. Saphris has a higher affinity for all aforementioned receptors compared to first-generation and second-generation antipsychotics except for 5-HT1A and 5-HT1B receptors.

Imprints


Drug: Saphris
Strength: 5 Mg (sublingual)
Pill Imprint: 5
Color: White
Shape: Round

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Drug: Saphris
Strength: 10 Mg (sublingual)
Pill Imprint: 10
Color: White
Shape: Round

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Drug: Saphris
Strength: 2.5 Mg (sublingual)
Pill Imprint: Logo (Hexagon)
Color: White
Shape: Round

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