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Spironolactone

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

The oral LD50 of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.

Imprints


Drug: Spironolactone
Strength: 25 Mg / 25 Mg
Pill Imprint: M 41
Color: Beige
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg / 25 Mg
Pill Imprint: MP 40
Color: Beige
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg / 25 Mg
Pill Imprint: 5014 G
Color: Beige
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg / 25 Mg
Pill Imprint: 5496 DAN DAN
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: 5880 V
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 25 MG
Pill Imprint: M 146
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: 58 81 V
Color: White
Shape: Elliptical / Oval

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: AN 511
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: AN 514
Color: Yellow
Shape: Round

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: 58 82 V
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: R 803
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: M 243
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: MP 35
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: AN 515
Color: Beige
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: 5011 G
Color: Yellow
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: GG 85
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: R 673
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: R672
Color: White
Shape: Elliptical / Oval

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: 5012 G
Color: Orange
Shape: Elliptical / Oval

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: M 437
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: 5013 G
Color: Orange
Shape: Round

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: MP 542
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: MYLAN 146 25
Color: White
Shape: Round

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: MP 303
Color: White
Shape: Elliptical / Oval

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: TL 218
Color: Brown
Shape: Round

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: TL 217
Color: Brown
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: TL 216
Color: Brown
Shape: Round

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Drug: Spironolactone
Strength: 100 Mg
Pill Imprint: ALDACTONE 100 SEARLE 1031
Color: Peach
Shape: Round

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Drug: Spironolactone
Strength: 25 Mg
Pill Imprint: ALDACTONE 25 SEARLE 1001
Color: Yellow
Shape: Round

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Drug: Spironolactone
Strength: 50 Mg
Pill Imprint: ALDACTONE 50 SEARLE 1041
Color: Orange
Shape: Elliptical / Oval

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