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Ultram

A narcotic analgesic proposed for moderate to severe pain. It may be habituating. Ultram is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form.

Ultram, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to μ-opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin. Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to μ-opioid receptors. In animal models, M1 is up to 6 times more potent than ultram in producing analgesia and 200 times more potent in μ-opioid binding. Opiate antagonist naloxone only partially antagonized ultram-induced analgesia.

LD50=350mg/kg (orally in mice)

Imprints


Drug: Ultram
Strength: 50 Mg
Pill Imprint: ULTRAM 06 59
Color: White
Shape: Elliptical / Oval

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Drug: Ultram
Strength: 200 Mg
Pill Imprint: 200 ER
Color: White
Shape: Round

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Drug: Ultram
Strength: 50 Mg
Pill Imprint: MCNEIL 659
Color: White
Shape: Capsule-shape

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Drug: Ultram
Strength: 100 Mg
Pill Imprint: 100 ER
Color: White
Shape: Round

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Drug: Ultram
Strength: 300 Mg
Pill Imprint: 300 ER
Color: White
Shape: Round

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Drug: Ultram
Strength: 50 Mg
Pill Imprint: ULTRAM 06 59
Color: White
Shape: Elliptical / Oval

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Drug: Ultram
Strength: 50 Mg
Pill Imprint: MCNEIL 659
Color: White
Shape: Capsule-shape

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Drug: Ultram
Strength: 250 Mg
Pill Imprint: WARRICK 1621
Color: White
Shape: Round

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Drug: Ultram
Strength: 330 Mg
Pill Imprint: WARRICK 1624 1624
Color: White
Shape: Elliptical / Oval

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Drug: Ultram
Strength: 125 Mg
Pill Imprint: C P 295
Color: White
Shape: Elliptical / Oval

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Drug: Ultram
Strength: 250 Mg
Pill Imprint: C P 296
Color: White
Shape: Elliptical / Oval

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Drug: Ultram
Strength: 250 Mg
Pill Imprint: E 14
Color: White
Shape: Round

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Drug: Ultram
Strength: 125 Mg
Pill Imprint: E 13
Color: White
Shape: Round

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