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Uroxatral

Uroxatral (INN , provided as the hydrochloride salt) is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH ). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.

Uroxatral is a quinazoline-derivative alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, uroxatral is a selective inhibitor of the alpha(1) subtype of alpha adrenergic receptors. In the human prostate, uroxatral antagonizes phenylephrine (alpha(1) agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1a adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that uroxatral competitively antagonized the pressor effects of phenylephrine (an alpha(1) agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of uroxatral results from a decrease in systemic vascular resistance and the parent compound uroxatral is primarily responsible for the antihypertensive activity.

Side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.

Imprints


Drug: Uroxatral
Strength: 10 Mg
Pill Imprint: X 10
Color: Yellow & White
Shape: Round

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