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Viagra

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH ). Viagra elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of viagra also help reduce symptoms of PAH .

Erections are controlled by the parasympathetic nervous system. Upon sexual stimulation, a decrease in vascular resistance is mediated by acetylcholine and nitric oxide resulting in vasodilation. The hemodynamic mechanism of an erection is comprised of five stages. During the latent stage, arterial and carvernous smooth muscle relaxation occurs. Vasodilation results in high levels of blood flow causing the penis to grow to its full size. This stage is called tumescence. During the full-erection stage, blood flow fills penis sinusoids and outflow is restricted. This is followed by the rigid-erection phase during which the cavernous muscles contract causing the penis to become rigid. Little blood flow occurs during this stage. During the final stage, detumescence, the cavernous muscles relax and blood flows out of the penis. Erectile dysfunction may occur when there is insufficient blood supply to the penis or when the penis is unable to prevent outflow of blood from the penis. Viagra is a specific inhibitor of PDE5, an enzyme responsible for the breakdown of cGMP to 5’-GMP. Increased levels of cGMP stimulate vasodilation and facilitate the generation and maintenance of erections. These vasodilatory effects also help decrease symptoms of PAH. Sildenfail also exhibits some activity against PDE6 (10 times less potentcy compared to PDE5), a PDE isoform found predmoninantly in the retina. This activity is responsible for the blue tinged vision experienced by users of viagra.

Imprints


Drug: Viagra
Strength: 100 Mg
Pill Imprint: Pfizer VGR 100
Color: Blue
Shape: Four-sided

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Drug: Viagra
Strength: 50 Mg
Pill Imprint: Pfizer VGR 50
Color: Blue
Shape: Four-sided

View Images & Details

Drug: Viagra
Strength: 25 Mg
Pill Imprint: Pfizer VGR 25
Color: Blue
Shape: Four-sided

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Drug: Viagra
Strength: 100 Mg
Pill Imprint: Pfizer VGR 100
Color: Blue
Shape: Four-sided

View Images & Details

Drug: Viagra
Strength: 50 Mg
Pill Imprint: Pfizer VGR 50
Color: Blue
Shape: Four-sided

View Images & Details

Drug: Viagra
Strength: 25 Mg
Pill Imprint: Pfizer VGR 25
Color: Blue
Shape: Four-sided

View Images & Details
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