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Xarelto

Xarelto is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.

Xarelto is an anticoagulant which binds directly to factor Xa. Thereafter, it effectively blocks the amplification of the coagulation cascade, preventing the formation of thrombus. Xarelto is a unqiue anticoagulant for two reasons. First of all, it is does not involve antithrombin III (ATIII) to exert its anticoagulant effects. Secondly, it is an oral agent whereas the widely used unfractionated heparin and low molecular weight heparins are for parenteral use only. Although the activated partial thromboplastin time (aPTT) and HepTest (a test developed to assay low molecular weight heparins) are prolonged in a dose-dependant manner, neither test is recommended for the assessment of the pharmacodynamic effects of xarelto. Anti-Xa activity and inhibition of anti-Xa activity monitoring is also not recommended despite being influenced by xarelto.

Excessive bleeding. Overdosages should be treated using activated charcoal and supportive measures such as mechanical compression and hemodynamic support. If bleeding is not controlled, the following procoagulants can be administered: activated prothrombin complex concentrate, prothrombin complex concentrate and recombinant factor VIIa. There is also a higher chance of post procedural hemorrhage compared to enoxaparin (1.55% vs. 1.39% respectively).

Imprints


Drug: Xarelto
Strength: 10 Mg
Pill Imprint: Logo 10 Xa
Color: Red
Shape: Round

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Drug: Xarelto
Strength: 20 Mg
Pill Imprint: Logo 20 Xa
Color: Red
Shape: Three-sided

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Drug: Xarelto
Strength: 15 Mg
Pill Imprint: Logo 15 Xa
Color: Red
Shape: Round

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