Call Is Confidential & Toll Free


Xifaxan is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller’s diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel syndrome (IBS -D) in adult women and men. It is marketed under the brand name Xifaxan by Salix Pharmaceuticals.

Xifaxan is a structural analog of rifampin and a non-systemic, gastrointestinal site-specific antibiotic. This non-systemic property of the drug is due to the addition of a pyridoimidazole ring, which renders it non-absorbable. Xifaxan acts by inhibiting bacterial ribonucleic acid (RNA) synthesis and contributes to restore intestinal microflora imbalance. Other studies have also shown xifaxan to be an pregnane X receptor (PXR) activator. As PXR is responsible for inhibiting the proinflammatory transcription factor NF-kappa B (NF-κB) and is inhibited in inflammatory bowel disease (IBD), xifaxan was proven to be effective for the treatment of IBS-D.

LD50 > 2 g/kg (orally, in rats)


Drug: Xifaxan
Strength: 550 Mg
Pill Imprint: Rfx
Color: Pink
Shape: Elliptical / Oval

View Images & Details

Drug: Xifaxan
Strength: 200 Mg
Pill Imprint: Sx
Color: Brown
Shape: Round

View Images & Details
Disclaimer: We strive to ensure that the content on pilladdictions.com is current and factual at the time it was written. However, because new information and discoveries are always becoming available, we are not making any representations or warranties with respect to this content. Please always rely on the guidance of your physician for information about the drugs you are taking and the impacts they may or may not have on your health.

Questions About Prescription Drug Addiction?

(888) 740-2069

Questions About Prescription Drug Addiction?