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Ziac

Ziac is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Ziac is structurally similar to metoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At lower doses (less than 20 mg daily), ziac selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with daily doses of 20 mg or greater. Unlike propranolol and pindolol, ziac does not exhibit membrane-stabilizing or sympathomimetic activity. Ziac possesses a single chiral centre and is administered as a racemic mixture. Only l-ziac exhibits significant β-blocking activity.

Ziac is a competitive, cardioselective β1-adrenergic antagonist. Activation of β1-receptors (located mainly in the heart) by epinephrine increases heart rate and the blood pressure causing the heart to consume more oxygen. β1-adrenergic blocking agents such as bisopolol lower the heart rate and blood pressure and may be used to reduce workload on the heart and hence oxygen demands. They are routinely prescribed in patients with ischemic heart disease. In addition, β1-selective blockers prevent the release of renin, a hormone produced by the kidneys causes constriction of blood vessels. Ziac is lipophilic and exhibits no intrinsic sympathomimetic activity (ISA) or membrane-stabilizing activity.

Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.

Imprints


Drug: Ziac
Strength: 2.5 Mg / 6.25 Mg
Pill Imprint: LL B 12
Color: Yellow
Shape: Round

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Drug: Ziac
Strength: 5 Mg / 6.25 Mg
Pill Imprint: B 50
Color: Pink
Shape: Round

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Drug: Ziac
Strength: 5 Mg / 6.25 Mg
Pill Imprint: LL B 13
Color: Pink
Shape: Round

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Drug: Ziac
Strength: 10 Mg / 6.25 Mg
Pill Imprint: B 40
Color: White
Shape: Round

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Drug: Ziac
Strength: 10 Mg / 6.25 Mg
Pill Imprint: LL B 14
Color: White
Shape: Round

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Drug: Ziac
Strength: 2.5 Mg / 6.25 Mg
Pill Imprint: B 47
Color: Yellow
Shape: Round

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