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Zofran

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Zofran is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serontonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema. The temporal relationship between the emetogenic action of emetogenic drugs and the release of serotonin, as well as the efficacy of antiemetic agents suggest that chemotherapeutic agents release serotonin from the enterochromaffin cells of the small intestine by causing degenerative changes in the GI tract. The serotonin then stimulates the vagal and splanchnic nerve receptors that project to the medullary vomiting center, as well as the 5-HT3 receptors in the area postrema, thus initiating the vomiting reflex, causing nausea and vomiting.

Low blood pressure and fainting, sudden blindness, severe constipation

Imprints


Drug: Zofran
Strength: 4 Mg
Pill Imprint: Zofran 4
Color: White
Shape: Elliptical / Oval

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Drug: Zofran
Strength: 8 Mg
Pill Imprint: ZOFRAN 8
Color: Yellow
Shape: Elliptical / Oval

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Drug: Zofran
Strength: 4 MG
Pill Imprint: Z4
Color: White
Shape: Round

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Drug: Zofran
Strength: 8 MG
Pill Imprint: Z8
Color: White
Shape: Round

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